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Alternative Promoter Use Governs The Expression Of Iglon Cell Adhesion Molecules In Histogenetic Fields Of The Embryonic Mouse Brain, T. Jagomäe, K. Singh, M.-A. Philips, M. Jayaram, K. Seppa, T. Tekko, Scott F. Gilbert, E. Vasar, K. Lilleväli

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The members of the IgLON superfamily of cell adhesion molecules facilitate fundamental cellular communication during brain development, maintain functional brain circuitry, and are associated with several neuropsychiatric disorders such as depression, autism, schizophrenia, and intellectual disabilities. Usage of alternative promoter-specific 1a and 1b mRNA isoforms in Lsamp, Opcml, Ntm, and the single promoter of Negr1 in the mouse and human brain has been previously described. To determine the precise spatiotemporal expression dynamics of Lsamp, Opcml, Ntm isoforms, and Negr1, in the developing brain, we generated isoform-specific RNA probes and carried out in situ hybridization in the developing (embryonic, E10.5, E11.5, …