Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Stephen J. Gould, Scott F. Gilbert
From Development To Evolution: The Re-Establishment Of The "Alexander Kowalevsky Medal", A. T. Mikhailov, Scott F. Gilbert
From Development To Evolution: The Re-Establishment Of The "Alexander Kowalevsky Medal", A. T. Mikhailov, Scott F. Gilbert
Biology Faculty Works
The Saint Petersburg Society of Naturalists has reinstated the Alexander O. Kowalevsky Medal. This article announces the winners of the first medals and briefly reviews the achievements of A.O. Kowalevsky,the Russian comparative embryologist whose studies on amphioxus, tunicates and germ layer homologies pioneered evolutionary embryology and confirmed the evolutionary continuity between invertebrates and vertebrates. In re-establishing this international award, the Society is pleased to recognize both the present awardees and the memory of Kowalevsky, whose work pointed to that we now call evolutionary developmental biology.
Analysis Of Protein Localization And Secretory Pathway Function Using The Yeast Saccharomyces Cerevisiae, Elizabeth Ann Vallen
Analysis Of Protein Localization And Secretory Pathway Function Using The Yeast Saccharomyces Cerevisiae, Elizabeth Ann Vallen
Biology Faculty Works
The isolation and characterization of mutants has been crucial in understanding a number of processes in the field of cell biology. In this exercise, students examine the effects of mutations in the secretory pathway on protein localization. Yeast strains deficient for synthesis of histidinol dehydrogenase are transformed with a plasmid encoding a chimeric protein. The chimera contains a signal sequence fused to histidinol dehydrogenase. A strain with a defect in the translocation of secretory proteins into the endoplasmic reticulum (ER) accumulates sufficient histidinol dehydrogenase in the cytoplasm to grow on media lacking histidine. In contrast, yeast proficient for secretion, or …