Life Sciences Commons^™

Biochemical Evaluation Of Drug Inhibition Of Abc Transporters, Maisa Correa De Oliveira

Biological Sciences Theses and Dissertations

Multidrug resistant (MDR) cancers often become resistant to pharmacologically and structurally diverse drugs by overexpressing members of the family of ATP Binding Cassette (ABC) transporters. These membrane pumps protect normal cells by actively exporting a large range of toxins out of the cells. Classic MDR is often correlated with the overexpression of three well-studied mammalian ABC transporters: P-glycoprotein (P-gp), Breast Cancer Resistant Protein (BCRP), and Multidrug Resistant Protein 1 (MRP1).

P-gp is the most studied ABC transporter, and the search for P-gp inhibitors as co-therapeutics to combat MDR has had little success after decades of studies. We previously used high-throughput …

Dynamic Mechanisms Of Multidrug Resistance In Human Cancers And Gram Negative Pathogens, Lauren Ammerman

Biological Sciences Theses and Dissertations

This dissertation focuses upon dynamic agents of multidrug resistance (MDR). We used a combination of in silico and in vitro techniques to investigate two membrane transporters that confer MDR – P-glycoprotein, which confers MDR in human cancers, and MtrD, which confers MDR in Neisseria gonorrhoeae. Inhibitors targeting both proteins have tremendous potential for use as co-therapeutics in the treatment of multidrug resistant cancers, or of multidrug resistant infections. However, previously identified inhibitors of P-gp have failed clinical trials due to off-target effects and associated toxicities. Furthermore, the molecular mechanism of antibiotic transport by MtrD is poorly understood, and this dearth …

Black Apollo Of Science: The Life Of Ernest Everett Just - Summarizing Timeline, Sumitography And Concept Poster, Lillie R. Jenkins

Perkins Faculty Research and Special Events

This two-part chronology is based on Kenneth R. Manning’s biography, Black Apollo of Science: The Life of Ernest Everett Just (1983). Like other such timelines, this one details Just’s life and pioneering research work. Additionally, and distinctively, this timetable lays out Just’s pioneering fund-seeking and his work mentoring African American female co-researchers (Part 1). A sumitography featuring the United States Postal Service’s postage stamp (1996) recognizes Just’s innovative thinking in biology (Part 2). Following this logic, the author includes a proof-of-concept poster commending E.E. Just’s work as a forward-thinking administrator. This timeline summarizes, chronicles, and aims to re-frame Just’s …