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Motor Neuron Synapse And Axon Defects In A C. Elegans Alpha-Tubulin Mutant, Renee Baran, Liliana Castelblanco, Garland Tang, Ian Shapiro, Alexandr Goncharov, Yishi Jin
Motor Neuron Synapse And Axon Defects In A C. Elegans Alpha-Tubulin Mutant, Renee Baran, Liliana Castelblanco, Garland Tang, Ian Shapiro, Alexandr Goncharov, Yishi Jin
Renee Baran
Regulation of microtubule dynamics underlies many fundamental cellular mechanisms including cell division, cell motility, and transport. In neurons, microtubules play key roles in cell migration, axon outgrowth, control of axon and synapse growth, and the regulated transport of vesicles and structural components of synapses. Loss of synapse and axon integrity and disruption of axon transport characterize many neurodegenerative diseases. Recently, mutations that specifically alter the assembly or stability of microtubules have been found to directly cause neurodevelopmental defects or neurodegeneration in vertebrates. We report here the characterization of a missense mutation in the C-terminal domain of C. elegans alpha-tubulin, tba-1(ju89), …