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Full-Text Articles in Life Sciences

Stability Of Delayed Virus Infection Model With A General Incidence Rate And Adaptive Immune Response, Zhimin Chen, Xiuxiang Liu, Zhongzhong Xie Dec 2018

Stability Of Delayed Virus Infection Model With A General Incidence Rate And Adaptive Immune Response, Zhimin Chen, Xiuxiang Liu, Zhongzhong Xie

Applications and Applied Mathematics: An International Journal (AAM)

We present the dynamical behaviors of a virus infection model with general infection rate, immune responses and two intracellular delays which describe the interactions of the HIV virus, target cells, CTL cells and antibodies within host. Three factors are incorporated in this model: (1) the intrinsic growth rate of uninfected cells, (2) a nonlinear incidence rate function considering both virus-tocell infection and cell-to-cell transmission, and (3) a nonlinear productivity and removal function. By the method of Lyapunov functionals and LaSalle’s invariance principle, we show that the global dynamics of the model is determined by the reproductive numbers for viral infection …


Parameter Estimation And Optimal Control Of The Dynamics Of Transmission Of Tuberculosis With Application To Cameroon, A. Temgoua, Y. Malong, J. Mbang, S. Bowong Dec 2018

Parameter Estimation And Optimal Control Of The Dynamics Of Transmission Of Tuberculosis With Application To Cameroon, A. Temgoua, Y. Malong, J. Mbang, S. Bowong

Applications and Applied Mathematics: An International Journal (AAM)

This paper deals with the problem of parameter estimation and optimal control of a tuberculosis (TB) model with seasonal fluctuations. We first present a uncontrolled TB model with seasonal fluctuations. We present the theoretical analysis of the uncontrolled TB model without seasonal fluctuations. After, we propose a numerical study to estimate the unknown parameters of the TB model with seasonal fluctuations according to demographic and epidemiological data from Cameroon. Simulation results are in good accordance with the seasonal variation of the new active reported cases of TB in Cameroon. Using this TB model with seasonality, the tuberculosis control is formulated …


Slip And Chemical Reaction Effects On Peristaltic Transport Of A Cou-Ple Stress Fluid Through A Permeable Medium With Complaint Wall, Gurunath Sankad, Mallinath Dhange Jun 2018

Slip And Chemical Reaction Effects On Peristaltic Transport Of A Cou-Ple Stress Fluid Through A Permeable Medium With Complaint Wall, Gurunath Sankad, Mallinath Dhange

Applications and Applied Mathematics: An International Journal (AAM)

In the present article, the effects of slip and homogeneous-heterogeneous chemical reaction on peristaltic pumping of a couple stress fluid through a permeable medium with complaint wall is studied as a model for transport phenomena occurring in the small intestine of human beings during digestion process. The mean effective coefficient of dispersion on simultaneous homo-geneous, heterogeneous chemical reactions has been derived through long wavelength assump-tion, and conditions of Taylor’s limit. The behaviors of key parameters on the mean effective dispersion coefficient have been examined through the graphs. It is found that slip and wall pa-rameters, and amplitude ratio favor the …


Global Stability Of Ebola Virus Disease Model With Contact Tracing And Quarantine, Chinwendu E. Madubueze, Anande R. Kimbir, Terhemen Aboiyar Jun 2018

Global Stability Of Ebola Virus Disease Model With Contact Tracing And Quarantine, Chinwendu E. Madubueze, Anande R. Kimbir, Terhemen Aboiyar

Applications and Applied Mathematics: An International Journal (AAM)

This study considers a deterministic model of Ebola Virus Disease (EVD) incorporating contact tracing and quarantine as interventions. The model analyze the existence and stability of Disease-Free Equilibrium (DFE) and Endemic Equilibrium (EE) states. The local stability of EE is established using centre manifold theorem. The global stability of the two equilibrium states are obtained by constructing the Lyapunov function. Numerical simulations are carried out to examine the impact of contact tracing and quarantine measures on the transmission dynamics of EVD. The result indicates that EVD could be eliminated faster when contact tracing and quarantine measures are implemented together.