Life Sciences Commons^™

Mathematical Modeling And Analysis Of Leukemia: Effect Of External Engineered T Cells Infusion, Manju Agarwal, Archana S. Bhadauria

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, a nonlinear model is proposed and analyzed to study the spread of Leukemia by considering the effect of genetically engineered patients T cells to attack cancer cells. The model is governed by four dependent variables namely; naive or susceptible blood cells, infected or dysfunctional blood cells, cancer cells and immune cells. The model is analyzed by using the stability theory of differential equations and numerical simulation. We have observed that the system is stable in the local and global sense if antigenicity rate or rate of stimulation of immune cells is greater than a threshold value dependent …