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Full-Text Articles in Life Sciences
A New Frontier For Fat: Dietary Palmitic Acid Induces Innate Immune Memory, Amy L. Seufert, Brooke A. Napier
A New Frontier For Fat: Dietary Palmitic Acid Induces Innate Immune Memory, Amy L. Seufert, Brooke A. Napier
Biology Faculty Publications and Presentations
Dietary saturated fats have recently been appreciated for their ability to modify innate immune cell function, including monocytes, macrophages, and neutrophils. Many dietary saturated fatty acids (SFAs) embark on a unique pathway through the lymphatics following digestion, and this makes them intriguing candidates for inflammatory regulation during homeostasis and disease. Specifically, palmitic acid (PA) and diets enriched in PA have recently been implicated in driving innate immune memory in mice. PA has been shown to induce long-lasting hyper-inflammatory capacity against secondary microbial stimuli in vitro and in vivo, and PA-enriched diets alter the developmental trajectory of stem cell progenitors in …
Exploring Mirna Function And Host Response To Coxiella Burnetii Infection, Madhur Sachan
Exploring Mirna Function And Host Response To Coxiella Burnetii Infection, Madhur Sachan
Dissertations and Theses
Alveolar macrophages attempt to control bacterial infection through a spectrum of defense processes, including induction of apoptosis, autophagy, inflammatory response, and nutrient sequestration. MicroRNAs (miRNAs), a class of small non-coding RNAs, are involved in a spectrum of physiological processes, including immune response to intracellular infections. However, whether microRNAs have any functions in host response to Coxiella burnetii infection is unknown. Coxiella burnetii is a highly infectious intracellular pathogen that causes Q fever, a zoonosis with a worldwide occurrence. In this work, I investigated the functions of miRNAs in host response to C. burnetii infection and found that miRNAs are an …