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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Tau Kinetics In Alzheimer's Disease, Daniel B. Hier, Sima Azizi, Matthew S. Thimgan, Donald C. Wunsch
Tau Kinetics In Alzheimer's Disease, Daniel B. Hier, Sima Azizi, Matthew S. Thimgan, Donald C. Wunsch
Chemistry Faculty Research & Creative Works
The Cytoskeletal Protein Tau is Implicated in the Pathogenesis of Alzheimer's Disease Which is Characterized by Intra-Neuronal Neurofibrillary Tangles Containing Abnormally Phosphorylated Insoluble Tau. Levels of Soluble Tau Are Elevated in the Brain, the CSF, and the Plasma of Patients with Alzheimer's Disease. to Better Understand the Causes of These Elevated Levels of Tau, We Propose a Three-Compartment Kinetic Model (Brain, CSF, and Plasma). the Model Assumes that the Synthesis of Tau Follows Zero-Order Kinetics (Uncorrelated with Compartmental Tau Levels) and that the Release, Absorption, and Clearance of Tau is Governed by First-Order Kinetics (Linearly Related to Compartmental Tau Levels). …
Pollutants Corrupt Resilience Pathways Of Aging In The Nematode C. Elegans, Andrea Scharf, Annette Limke, Karl Heinz Guehrs, Anna Von Mikecz
Pollutants Corrupt Resilience Pathways Of Aging In The Nematode C. Elegans, Andrea Scharf, Annette Limke, Karl Heinz Guehrs, Anna Von Mikecz
Biological Sciences Faculty Research & Creative Works
Delaying aging while prolonging health and lifespan is a major goal in aging research. One promising strategy is to focus on reducing negative interventions such as pollution and their accelerating effect on age-related degeneration and disease. Here, we used the short-lived model organism C. elegans to analyze whether two candidate pollutants corrupt general aging pathways. We show that the emergent pollutant silica nanoparticles (NPs) and the classic xenobiotic inorganic mercury reduce lifespan and cause a premature protein aggregation phenotype. Comparative mass spectrometry revealed that increased insolubility of proteins with important functions in proteostasis is a shared phenotype of intrinsic- and …
Pollution — Bring The Field Into The Lab, Anna Von Mikecz, Andrea Scharf
Pollution — Bring The Field Into The Lab, Anna Von Mikecz, Andrea Scharf
Biological Sciences Faculty Research & Creative Works
Letter to the Editor
Bio-Membrane Internalization Mechanisms Of Arginine-Rich Cell-Penetrating Peptides In Various Species, Betty Revon Liu, Shiow Her Chiou, Yue-Wern Huang, Han Jung Lee
Bio-Membrane Internalization Mechanisms Of Arginine-Rich Cell-Penetrating Peptides In Various Species, Betty Revon Liu, Shiow Her Chiou, Yue-Wern Huang, Han Jung Lee
Biological Sciences Faculty Research & Creative Works
Recently, membrane-active peptides or proteins that include antimicrobial peptides (AMPs), cytolytic proteins, and cell-penetrating peptides (CPPs) have attracted attention due to their potential applications in the biomedical field. Among them, CPPs have been regarded as a potent drug/molecules delivery system. Various cargoes, such as DNAs, RNAs, bioactive proteins/peptides, nanoparticles and drugs, can be carried by CPPs and delivered into cells in either covalent or non-covalent manners. Here, we focused on four arginine-rich CPPs and reviewed the mechanisms that these CPPs used for intracellular uptake across cellular plasma membranes. The varying trans-duction efficiencies of them alone or with cargoes were discussed, …
Assessing The Effects Of Age And Sex On Mtbi Severity, Jennifer Harrell
Assessing The Effects Of Age And Sex On Mtbi Severity, Jennifer Harrell
Honors Academy
“Mild Traumatic Brain Injury (mTBI) accounts for 70-90% of TBIs recorded in the last two decades. Subjection to continued mTBIs could result in severe comorbidities appearing years later. Current research on mTBI shows significant male sex and single age skew in murine animal models. Using the Missouri Blast Model, mice were inflicted with mTBI and evaluated using standard behavior tests and a novel method not previously used for mTBI with an open blast model. With both methods, a larger clinical difference was found between age groups than sex. We were also able to show that the novel tracking method was …
Validation Of Edna Metabarcoding : A Comparison To Traditional Survey Methods In Ozark Streams, Veronica Marian Lee
Validation Of Edna Metabarcoding : A Comparison To Traditional Survey Methods In Ozark Streams, Veronica Marian Lee
Masters Theses
Environmental DNA (eDNA) sampling provides a method for assessing fish communities that has potential as a supplement to traditional sampling methods due to its ability to save time as well as its non-invasive nature. This is a method in which from just one sample, eDNA from multiple individual species are able to be sequenced in tandem and the resulting reads identified to describe a community. In order to evaluate this technique and its efficacy for monitoring fish community diversity, we collected water samples alongside surveys performed by the Missouri Department of Conservation sampling program in summers 2020-21. DNA were extracted …