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Perturbing Microtubule Integrity Blocks Amp-Activated Protein Kinase-Induced Meiotic Resumption In Cultured Mouse Oocytes, Ru Ya, Stephen Downs
Perturbing Microtubule Integrity Blocks Amp-Activated Protein Kinase-Induced Meiotic Resumption In Cultured Mouse Oocytes, Ru Ya, Stephen Downs
Biological Sciences Faculty Research and Publications
The oocyte meiotic spindle is comprised of microtubules (MT) that bind chromatin and regulate both metaphase plate formation and karyokinesis during meiotic maturation; however, little information is known about their role in meiosis reinitiation. This study was conducted to determine if microtubule integrity is required for meiotic induction and to ascertain how it affects activation of AMP-activated protein kinase (AMPK), an important participant in the meiotic induction process. Treatment with microtubule-disrupting agents nocodazole and vinblastine suppressed meiotic resumption in a dose-dependent manner in both arrested cumulus cell-enclosed oocytes (CEO) stimulated with follicle-stimulating hormone (FSH) and arrested denuded oocytes (DO) stimulated …