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Full-Text Articles in Life Sciences
Activation Of High And Low Affinity Dopamine Receptors Generates A Closed Loop That Maintains A Conductance Ratio And Its Activity Correlate, Wulf-Dieter C. Krenz, Ryan M. Hooper, Anna R. Parker, Astrid A. Prinz, Deborah J. Baro
Activation Of High And Low Affinity Dopamine Receptors Generates A Closed Loop That Maintains A Conductance Ratio And Its Activity Correlate, Wulf-Dieter C. Krenz, Ryan M. Hooper, Anna R. Parker, Astrid A. Prinz, Deborah J. Baro
Biology Faculty Publications
Neuromodulators alter network output and have the potential to destabilize a circuit. The mechanisms maintaining stability in the face of neuromodulation are not well described. Using the pyloric network in the crustacean stomatogastric nervous system, we show that dopamine (DA) does not simply alter circuit output, but activates a closed loop in which DA-induced alterations in circuit output consequently drive a change in an ionic conductance to preserve a conductance ratio and its activity correlate. DA acted at low affinity type 1 receptors (D1Rs) to induce an immediate modulatory decrease in the transient potassium current (I A ) of a …