Open Access. Powered by Scholars. Published by Universities.®
Flavivirus replication; nonstructural proteins; nonstructural protein interactions; cis-acting RNA sequences; conserved RNA structures; host factors; RNA-protein interactions; host cell remodeling
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Replication Cycle And Molecular Biology Of The West Nile Virus, Margo A. Brinton
Replication Cycle And Molecular Biology Of The West Nile Virus, Margo A. Brinton
Biology Faculty Publications
West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae. Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment. Although much has been learned about virion structure and virion-endosomal membrane fusion, the cell receptor(s) used have not been definitively identified and little is known about the early stages of the virus replication cycle. Members of the genus Flavivirus differ from members of the two other genera of the family by the lack of a genomic internal ribosomal entry sequence and the creation of invaginations in the ER membrane rather than …