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Full-Text Articles in Life Sciences
Role Of Hsp70 And The Tlr4-Md2 Complex In The Vasculature: From Function To Dysfunction In Diabetes, Amanda Almeida De Oliveira
Role Of Hsp70 And The Tlr4-Md2 Complex In The Vasculature: From Function To Dysfunction In Diabetes, Amanda Almeida De Oliveira
Theses and Dissertations
Diabetes impairs vascular functionality, which contributes to the pathophysiology of its associated complications. Recently, it was suggested that innate immune receptors assist in the development of diabetic vasculopathies, which sustains the pro-inflammatory state of the disease. Among these receptors, Toll-like receptor 4 (TLR4) is a strategic player as its activation prime the release of inflammatory mediators and reactive oxygen species (ROS), which are well-known pathological mechanisms linked to diabetic complications. The TLR4-Myeloid differentiation factor 2 (MD2) complex has gained much attention over the last decade, primarily because it interacts with self-produced molecules. In vascular tissues, the Heat-shock protein 70 (HSP70) …
Transcriptomic And Proteomic Identification Of Signaling Molecules Involved In Egg Activation In The Sea Star, Patiria Miniata, Lauren Shea Bates
Transcriptomic And Proteomic Identification Of Signaling Molecules Involved In Egg Activation In The Sea Star, Patiria Miniata, Lauren Shea Bates
Theses and Dissertations
During egg activation in all species, the critical mechanism to restart the zygote metabolism and prevent polyspermy is an intracellular Ca2+ increase. The signaling molecules, including the receptors on the sperm and egg, leading to the Ca2+ rise are not fully known. In the sea star, Patiria miniata, SFK1, SFK3, and PLCγ are known signaling molecules who are responsible for causing the internal Ca2+ rise from the endoplasmic reticulum. These three proteins share common features including signaling through SH2 domains and their activity is controlled by tyrosine phosphorylation. Using transcriptomics and phospho-proteomics to search for more molecules with these same …
Spatial Ecology And Stable Isotope Composition Of Cetaceans In The Bohol Sea, Edna Sabater
Spatial Ecology And Stable Isotope Composition Of Cetaceans In The Bohol Sea, Edna Sabater
Theses and Dissertations
Studies on Philippine cetaceans (i.e., whales and dolphins) began in the early 1980s, and have resulted in the location and identification of species in Philippine waters. However, the population estimates of most of the cetacean species are uncertain, which is important in evaluating whether the populations are stable, decreasing, or increasing in relation to potential threats and conservation measures. I conducted line-transect surveys between 2010 and 2019 in the Bohol Sea, Philippines. A total of 2009.5 km survey efforts were made, which covered an area of 8041 km2 throughout the 5-year survey period. Distance sampling methods estimated the total abundance …
Late Quaternary Vegetation And Climate History From The Lake Junín Plateau, Jacob Daniel Schiferl
Late Quaternary Vegetation And Climate History From The Lake Junín Plateau, Jacob Daniel Schiferl
Theses and Dissertations
Whether the Andean ecosystem is resilient against future climate change remains unclear. A 2018 IPCC special report identified that warming more than 1.5ºC above pre-industrial temperatures by the year 2100 would be a major disrupter to natural systems, by causing more frequent extreme heatwaves, prolonged droughts, extreme precipitation events, and biome shifts. The tropical Andes will likely exceed this 1.5ºC threshold within the next century, threatening the diverse and endemic biota found in one of the world’s largest biodiversity hot spots. Yet few studies have examined the response of the Andean system through past interglacial periods when the temperatures were …
Roles Of Holocene Climate And Pastoralism In Shaping Andean Landscapes, Courtney Renee Shadik
Roles Of Holocene Climate And Pastoralism In Shaping Andean Landscapes, Courtney Renee Shadik
Theses and Dissertations
The Holocene (c. 11,700years ago –present) was a time rich in Andean climatic, environmental, and cultural changes. Assemblages were reforming after the last ice age, millennial scale wet and dry events caused the largest changes in lake level of the last 100,000 years, and humans came to dominate the landscape. Against the backdrop of ecological change, this study asks the following questions-Was the onset of camelid domestication associated with mid-Holocene aridity? Are modern, high-elevation vegetation assemblages a product of manufactured landscapes? What are the long-term effects of intense agropastoralism on paleoecological reconstructions of Andean landscapes? Did Holocene agropastoral domesticates coevolve? …