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Role Of Drosophila Rap/Fzr (Cdh1) In Retinal Axon Targeting And Its Interactions With Loco, Liprin-A And Ras, Marta Gronska
Role Of Drosophila Rap/Fzr (Cdh1) In Retinal Axon Targeting And Its Interactions With Loco, Liprin-A And Ras, Marta Gronska
Dissertations and Theses
The development of the wild type Drosophila compound eye involves stereotypical targeting of photoreceptor axons to the specific layers of the optic ganglion, medulla and lamina, in the third instar larvae. To test the hypothesis that ubiquitin ligases play an important role during retinal axon targeting we have examined the patterns of axon targeting in the developing eye of the retina aberrant in pattern (rap/fzr) mutants. Rap/Fzr is a homolog of mammalian Cdh1, an activator of anaphase promoting complex (APC), an E3 ubiquitin ligase. Previous work has shown that Rap/Fzr is required in cell cycle regulation, glia differentiation and pattern …