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Full-Text Articles in Life Sciences
Role Of Moa-1, An Anti-Phosphatase, And Apl-1, An App-Related Protein, In Morphogenesis And Mating Behavior In Caenorhabditis Elegans, Valerie C. Moscoso
Role Of Moa-1, An Anti-Phosphatase, And Apl-1, An App-Related Protein, In Morphogenesis And Mating Behavior In Caenorhabditis Elegans, Valerie C. Moscoso
Dissertations and Theses
Alzheimer's disease is a neurodegenerative disease that affects more than 30 million people globally. The disease is characterized by an accumulation of extracellular beta-amyloid peptide plaques and intracellular neurofibrillary tangles in the brain. The beta-amyloid peptide is derived from a larger precursor protein, the amyloid precursor protein (APP). Mutations in APP have been correlated with Alzheimer's disease. Due to the presence of two paralogues, APLP1 and APLP2, which have overlapping functions, the normal function of APP is difficult to elucidate. Knockout of the entire APP gene family in mice results in lethality and developmental defects, indicating that the APP gene …
Optimizing Crispr/Cas9 Gene Targeting To Investigate Cone Photoreceptor Development In The Chick Retina, Diana Y. Kim
Optimizing Crispr/Cas9 Gene Targeting To Investigate Cone Photoreceptor Development In The Chick Retina, Diana Y. Kim
Dissertations and Theses
Many human eye conditions result in the loss of vision, due to the degeneration of cone photoreceptors in the retina. Thus, the development of methods to regenerate these cone photoreceptors is an active area of study. In order to find ways to regenerate cones, the molecular pathways and gene regulatory networks that a retinal progenitor cell takes to develop into a postmitotic cone photoreceptor needs to be well understood. In an attempt to answer this question, this paper studies the effect of CRISPR/Cas9-mediated mutagenesis of two key transcription factors, Otx2 and Nr2e3, on retinal progenitor cells and cone photoreceptors throughout …