Life Sciences Commons^™

Calculating Expected Dna Remnants From Ancient Founding Events In Human Population Genetics, Nathan C. Sheffield, Keith A. Crandall, Andrew Stacey

Faculty Publications

Background- Recent advancements in sequencing and computational technologies have led to rapid generation and analysis of high quality genetic data. Such genetic data have achieved wide acceptance in studies of historic human population origins and admixture. However, in studies relating to small, recent admixture events, genetic factors such as historic population sizes, genetic drift, and mutation can have pronounced effects on data reliability and utility. To address these issues we conducted genetic simulations targeting influential genetic parameters in admixed populations. Results- We performed a series of simulations, adjusting variable values to assess the affect of these genetic parameters on current …