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Full-Text Articles in Life Sciences
Calculating Expected Dna Remnants From Ancient Founding Events In Human Population Genetics, Nathan C. Sheffield, Keith A. Crandall, Andrew Stacey
Calculating Expected Dna Remnants From Ancient Founding Events In Human Population Genetics, Nathan C. Sheffield, Keith A. Crandall, Andrew Stacey
Faculty Publications
Background- Recent advancements in sequencing and computational technologies have led to rapid generation and analysis of high quality genetic data. Such genetic data have achieved wide acceptance in studies of historic human population origins and admixture. However, in studies relating to small, recent admixture events, genetic factors such as historic population sizes, genetic drift, and mutation can have pronounced effects on data reliability and utility. To address these issues we conducted genetic simulations targeting influential genetic parameters in admixed populations. Results- We performed a series of simulations, adjusting variable values to assess the affect of these genetic parameters on current …
Many Species In One: Dna Barcoding Overestimates The Number Of Species When Nuclear Mitochondrial Pseudogenes Are Coamplified, Michael F. Whiting, Hojun Song, Keith A. Crandall, Jennifer E. Buhay
Many Species In One: Dna Barcoding Overestimates The Number Of Species When Nuclear Mitochondrial Pseudogenes Are Coamplified, Michael F. Whiting, Hojun Song, Keith A. Crandall, Jennifer E. Buhay
Faculty Publications
Nuclear mitochondrial pseudogenes (numts) are nonfunctional copies of mtDNA in the nucleus that have been found in major clades of eukaryotic organisms.
Double-Stranded Rna-Activated Protein Kinase Pkr Of Fishes And Amphibians: Varying The Number Of Double-Stranded Rna Binding Domains And Lineage-Specific Duplications, Loubna Tazi, Stefan Rothenburg, Nikolaus Deigendesch, Madhusudan Dey, Thomas E. Dever
Double-Stranded Rna-Activated Protein Kinase Pkr Of Fishes And Amphibians: Varying The Number Of Double-Stranded Rna Binding Domains And Lineage-Specific Duplications, Loubna Tazi, Stefan Rothenburg, Nikolaus Deigendesch, Madhusudan Dey, Thomas E. Dever
Faculty Publications
Double-stranded (ds) RNA, generated during viral infection, binds and activates the mammalian anti-viral protein kinase PKR, which phosphorylates the translation initiation factor eIF2alpha leading to the general inhibition of protein synthesis. Although PKR-like activity has been described in fish cells, the responsible enzymes eluded molecular characterization until the recent discovery of goldfish and zebrafish PKZ, which contain Z-DNA-binding domains instead of dsRNA-binding domains (dsRBDs). Fish and amphibian PKR genes have not been described so far. Results- Here we report the cloning and identification of 13 PKR genes from 8 teleost fish and amphibian species, including zebrafish, demonstrating the coexistence of …