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Full-Text Articles in Life Sciences
Notch Family Members Follow Stringent Requirements For Intracellular Domain Dimerization At Sequence-Paired Sites, Jacob J. Crow, Allan R. Albig
Notch Family Members Follow Stringent Requirements For Intracellular Domain Dimerization At Sequence-Paired Sites, Jacob J. Crow, Allan R. Albig
Biology Faculty Publications and Presentations
Notch signaling is essential for multicellular life, regulating core functions such as cellular identity, differentiation, and fate. These processes require highly sensitive systems to avoid going awry, and one such regulatory mechanism is through Notch intracellular domain dimerization. Select Notch target genes contain sequence-paired sites (SPS); motifs in which two Notch transcriptional activation complexes can bind and interact through Notch’s ankyrin domain, resulting in enhanced transcriptional activation. This mechanism has been mostly studied through Notch1, and to date, the abilities of the other Notch family members have been left unexplored. Through the utilization of minimalized, SPS-driven luciferase assays, we were …
Signaling And Other Functions Of Lipids In Autophagy: A Review, Alejandro Soto-Avellaneda, Brad E. Morrison
Signaling And Other Functions Of Lipids In Autophagy: A Review, Alejandro Soto-Avellaneda, Brad E. Morrison
Biology Faculty Publications and Presentations
The process of autophagy is integral to cellular function. In this process, proteins, organelles, and metabolites are engulfed in a lipid vesicle and trafficked to a lysosome for degradation. Its central role in protein and organelle homeostasis has piqued interest for autophagy dysfunction as a driver of pathology for a number of diseases including cancer, muscular disorders, neurological disorders, and non-alcoholic fatty liver disease. For much of its history, the study of autophagy has centered around proteins, however, due to advances in mass spectrometry and refined methodologies, the role of lipids in this essential cellular process has become more apparent. …
Enhanced Hyaluronan Signaling And Autophagy Dysfunction By Vps35 D620n, Abir A. Rahman, Alejandro Soto-Avellaneda, Iva Stojkovska, Nathan K. Lai, Joshua E. Albright, Abby R. Webb, Emily Oe, Jacob P. Valarde, Alexandra E. Oxford, Paige E. Urquhart, Brandon Wager, Connor Brown, Isabella Amado, Peyton Vasquez, Nicholas Lehning, Xinzhu Pu, Brad E. Morrison
Enhanced Hyaluronan Signaling And Autophagy Dysfunction By Vps35 D620n, Abir A. Rahman, Alejandro Soto-Avellaneda, Iva Stojkovska, Nathan K. Lai, Joshua E. Albright, Abby R. Webb, Emily Oe, Jacob P. Valarde, Alexandra E. Oxford, Paige E. Urquhart, Brandon Wager, Connor Brown, Isabella Amado, Peyton Vasquez, Nicholas Lehning, Xinzhu Pu, Brad E. Morrison
Biology Faculty Publications and Presentations
The motor features of Parkinson’s disease (PD) result from the loss of dopaminergic (DA) neurons in the substantia nigra with autophagy dysfunction being closely linked to this disease. A PD-causing familial mutation in VPS35 (D620N) has been reported to inhibit autophagy. In order to identify signaling pathways responsible for this autophagy defect, we performed an unbiased screen using RNA sequencing (RNA-Seq) of wild-type or VPS35 D620N-expressing retinoic acid-differentiated SH-SY5Y cells. We report that VPS35 D620N-expressing cells exhibit transcriptome changes indicative of alterations in extracellular matrix (ECM)-receptor interaction as well as PI3K-AKT signaling, a pathway known to regulate autophagy. Hyaluronan (HA) …
Low Intensity Vibrations Augment Mesenchymal Stem Cell Proliferation And Differentiation Capacity During In Vitro Expansion, Guniz Bas, Stacie Loisate, Stephanie F. Hudon, Kali Woods, Eric J. Hayden, Xinzhu Pu, Richard Beard, Julia T. Oxford, Gunes Uzer
Low Intensity Vibrations Augment Mesenchymal Stem Cell Proliferation And Differentiation Capacity During In Vitro Expansion, Guniz Bas, Stacie Loisate, Stephanie F. Hudon, Kali Woods, Eric J. Hayden, Xinzhu Pu, Richard Beard, Julia T. Oxford, Gunes Uzer
Biology Faculty Publications and Presentations
A primary component of exercise, mechanical signals, when applied in the form of low intensity vibration (LIV), increases mesenchymal stem cell (MSC) osteogenesis and proliferation. While it is generally accepted that exercise effectively combats the deleterious effects of aging in the musculoskeletal system, how long-term exercise affects stem cell aging, which is typified by reduced proliferative and differentiative capacity, is not well explored. As a first step in understanding the effect of long-term application of mechanical signals on stem cell function, we investigated the effect of LIV during in vitro expansion of MSCs. Primary MSCs were subjected to either a …
Clinical Trials In Alzheimer’S Disease: A Hurdle In The Path Of Remedy, Alexandra E. Oxford, Erica S. Stewart, Troy T. Rohn
Clinical Trials In Alzheimer’S Disease: A Hurdle In The Path Of Remedy, Alexandra E. Oxford, Erica S. Stewart, Troy T. Rohn
Biology Faculty Publications and Presentations
Human clinical trials seek to ameliorate the disease states and symptomatic progression of illnesses that, as of yet, are largely untreatable according to clinical standards. Ideally, clinical trials test “disease-modifying drugs,” i.e., therapeutic agents that specifically modify pathological features or molecular bases of the disease and would presumably have a large impact on disease progression. In the case of Alzheimer’s disease (AD), however, this approach appears to have stalled progress in the successful development of clinically useful therapies. For the last 25 years, clinical trials involving AD have centered on beta-amyloid (Aβ) and the Aβ hypothesis of …
Gateway Scholarships In Biological Sciences: Year 3 Annual Report, Vicki Stieha, Julia Oxford, Amy Ulappa, Brittnee Earl, Jennifer Forbey, Laura Bond, Kevin Feris, Jocelyn Cullers
Gateway Scholarships In Biological Sciences: Year 3 Annual Report, Vicki Stieha, Julia Oxford, Amy Ulappa, Brittnee Earl, Jennifer Forbey, Laura Bond, Kevin Feris, Jocelyn Cullers
Biology Faculty Publications and Presentations
This report summarizes grant activities, progress toward goals, and broader impacts of the Gateway Scholars Program in the Boise State Department of Biological Sciences during the 2019-20 academic year.
Evaluation Of The Efficacy Of A Cholera Toxin-Based Staphylococcus Aureus Vaccine Against Bovine Intramammary Challenge, Hussain A. Alabdullah, Elise Overgaard, Danielle Scarbrough, Janet E. Williams, Omid Mohammad Mousa, Gary Dunn, Laura Bond, Mark A. Mcguire, Juliette K. Tinker
Evaluation Of The Efficacy Of A Cholera Toxin-Based Staphylococcus Aureus Vaccine Against Bovine Intramammary Challenge, Hussain A. Alabdullah, Elise Overgaard, Danielle Scarbrough, Janet E. Williams, Omid Mohammad Mousa, Gary Dunn, Laura Bond, Mark A. Mcguire, Juliette K. Tinker
Biology Faculty Publications and Presentations
Staphylococcus aureus (S. aureus) is a primary agent of bovine mastitis and a source of significant economic loss for the dairy industry. We previously reported antigen-specific immune induction in the milk and serum of dairy cows following vaccination with a cholera toxin A2 and B subunit (CTA2/B) based vaccine containing the iron-regulated surface determinant A (IsdA) and clumping factor A (ClfA) antigens of S. aureus (IsdA + ClfA-CTA2/B). The goal of the current study was to assess the efficacy of this vaccine to protect against S. aureus infection after intramammary challenge. Six mid-lactation …