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Full-Text Articles in Life Sciences
Automating Pharmacokinetic Predictions In Artemisia, Celin Younan
Automating Pharmacokinetic Predictions In Artemisia, Celin Younan
Boise State University Theses and Dissertations
Pharmacokinetics (PK) is the time course of a compound in the body that is dependent on mechanisms of absorption, distribution, metabolism, and excretion or ADME. A thorough understanding of PK is essential to predict the consequences of organisms exposed to chemicals. In medicine, predictions of PK of drugs allows us to properly prescribe drug treatments. In toxicology, PK allows us to predict the potential exposure of environmental contaminants and how they may affect organisms at the time of exposure or in the future. Chemical ecology could benefit from computational predictions of PK to better understand which plants are consumed or …
The Role Of Decorin And Biglycan In Cns Angiogenesis And Eae Recovery, Kristina Chapman
The Role Of Decorin And Biglycan In Cns Angiogenesis And Eae Recovery, Kristina Chapman
Boise State University Theses and Dissertations
Multiple Sclerosis (MS) is a severe demyelinating disease of the Central Nervous System (CNS) associated with an autoimmune response directed against myelin antigens. Angiogenesis, the formation of new blood vessels from preexisting ones, is a vital process for tissue regeneration and wound healing but is a pathological hallmark of both MS and an MS mouse model, experimental autoimmune encephalomyelitis (EAE). This type of aberrant angiogenesis is a fundamental event during an inflammatory injury, which is mutually dependent upon the intrusion of inflammatory molecules, disruption of the blood-brain barrier (BBB), and immature vessel formation. In the EAE recovery phase, this process …
Understanding Temporal Dynamics Of Plant Specialized Metabolites In Response To Simulated Browsing In Winter, Bryanna Hope Bright
Understanding Temporal Dynamics Of Plant Specialized Metabolites In Response To Simulated Browsing In Winter, Bryanna Hope Bright
Boise State University Theses and Dissertations
Plants are continually defending themselves from the herbivores that consume them, often using an array of plant specialized metabolites (PSMs). Volatile organic compounds, including monoterpenes, are one such type of PSMs that can be emitted and induced by plants in response to mechanical damage and herbivory. These volatiles serve as direct defenses against herbivores and can alert neighboring plants about potential threats, resulting in protection against future attacks. However, how these chemicals change over time in response to browsing by vertebrates in the winter has received limited attention and is crucial to interpreting how monoterpenes defend plants against vertebrate herbivores. …