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Articles 1 - 22 of 22
Full-Text Articles in Life Sciences
Immunolocalization Of An Amino-Terminal Fragment Of Apolipoprotein E In The Pick's Disease Brain, Troy T. Rohn, Ryan J. Day, Lindsey W. Catlin, Raquel J. Brown, Alexander J. Rajic, Wayne W. Poon
Immunolocalization Of An Amino-Terminal Fragment Of Apolipoprotein E In The Pick's Disease Brain, Troy T. Rohn, Ryan J. Day, Lindsey W. Catlin, Raquel J. Brown, Alexander J. Rajic, Wayne W. Poon
Biology Faculty Publications and Presentations
Although the risk factor for apolipoprotein E (apoE) polymorphism in Alzheimer's disease (AD) has been well described, the role that apoE plays in other neurodegenerative diseases, including Pick's disease, is not well established. To examine a possible role of apoE in Pick's disease, an immunohistochemical analysis was performed utilizing a novel site-directed antibody that is specific for an amino-terminal fragment of apoE. Application of this antibody, termed the amino-terminal apoE cleavage fragment (nApoECF) antibody, consistently labeled Pick bodies within area CA1 of the hippocampus in 4 of the 5 cases examined. Co-localization of the nApoECF antibody with PHF-1, a general …
Comparative Genome Analysis Of Ciprofloxacin-Resistant Pseudomonas Aeruginosa Reveals Genes Within Newly Identified High Variability Regions Associated With Drug Resistance Development, Hsun-Cheng Su, Jainab Khatun, Dona M. Kanavy, Morgan C. Giddings
Comparative Genome Analysis Of Ciprofloxacin-Resistant Pseudomonas Aeruginosa Reveals Genes Within Newly Identified High Variability Regions Associated With Drug Resistance Development, Hsun-Cheng Su, Jainab Khatun, Dona M. Kanavy, Morgan C. Giddings
Biology Faculty Publications and Presentations
The alarming rise of ciprofloxacin-resistant Pseudomonas aeruginosa has been reported in several clinical studies. Though the mutation of resistance genes and their role in drug resistance has been researched, the process by which the bacterium acquires high-level resistance is still not well understood. How does the genomic evolution of P. aeruginosa affect resistance development? Could the exposure of antibiotics to the bacteria enrich genomic variants that lead to the development of resistance, and if so, how are these variants distributed through the genome? To answer these questions, we performed 454 pyrosequencing and a whole genome analysis both before and after …
Protargol Synthesis: An In-House Protocol, Xuming Pan, William A. Bourland, Weibo Song
Protargol Synthesis: An In-House Protocol, Xuming Pan, William A. Bourland, Weibo Song
Biology Faculty Publications and Presentations
The protargol staining method has proved to be indispensable for revealing the cellular structures of a variety of protozoa, especially the flagellates and ciliates. Protargol provides permanent stains of a variety of cellular structures: nuclei, extrusomes, basal bodies, and microfilamentous constituents of cells. Together with the older silver nitrate methods, protargol impregnations have provided the basis for the detailed descriptions of nearly all ciliates to date. The performance of commercially available preparations has varied widely. Recently, suppliers have stopped stocking the effective forms of protargol resulting in a worldwide shortage. Thus, it has become necessary for protistologists to explore on-site …
Serdemetan Antagonizes The Mdm2-Hif1Α Axis Leading To Decreased Levels Of Glycolytic Enzymes, Allan R. Albig
Serdemetan Antagonizes The Mdm2-Hif1Α Axis Leading To Decreased Levels Of Glycolytic Enzymes, Allan R. Albig
Biology Faculty Publications and Presentations
Serdemetan (JNJ-26854165), an antagonist to Mdm2, was anticipated to promote the activation of p53. While regulation of p53 by Mdm2 is important, Mdm2 also regulates numerous proteins involved in diverse cellular functions. We investigated if Serdemetan would alter the Mdm2-HIF1α axis and affect cell survival in human glioblastoma cells independently of p53. Treatment of cells with Serdemetan under hypoxia resulted in a decrease in HIF1α levels. HIF1α downstream targets, VEGF and the glycolytic enzymes (enolase, phosphoglycerate kinase1/2, and glucose transporter 1), were all decreased in response to Serdemetan. The involvement of Mdm2 in regulating gene expression of glycolytic enzymes raises …
Autism As The Early Closure Of A Neuroplastic Critical Period Normally Seen In Adolescence, Julia Marie Berger, Troy T. Rohn, Julia Thom Oxford
Autism As The Early Closure Of A Neuroplastic Critical Period Normally Seen In Adolescence, Julia Marie Berger, Troy T. Rohn, Julia Thom Oxford
Biology Faculty Publications and Presentations
The most severe cases of autism are diagnosed by extreme social dysfunction and other behavioral abnormalities. A number of genetic studies have been conducted to correlate behavioral phenotypes to genetic dysfunctions, but no “autism gene” has yet been discovered. In addition, environmental factors have been found to influence the development of autistic traits with high probability. This review will examine the role of a shortened period of neuroplasticity as a unifying feature of the autistic phenotype. The neuroplastic period of interest normally extends into adolescence, allowing for neural integration and the development of language and social skills. Early closure of …
Impacts Of An Ethanol-Blended Fuel Release On Groundwater And Fate Of Produced Methane: Simulation Of Field Observations, Kevin P. Feris
Impacts Of An Ethanol-Blended Fuel Release On Groundwater And Fate Of Produced Methane: Simulation Of Field Observations, Kevin P. Feris
Biology Faculty Publications and Presentations
[1] In a field experiment at Vandenberg Air Force Base (VAFB) designed to mimic the impact of a small-volume release of E10 (10% ethanol and 90% conventional gasoline), two plumes were created by injecting extracted groundwater spiked with benzene, toluene, and o-xylene, abbreviated BToX (no-ethanol lane) and BToX plus ethanol (with-ethanol lane) for 283 days. We developed a reactive transport model to understand processes controlling the fate of ethanol and BToX. The model was calibrated to the extensive field data set and accounted for concentrations of sulfate, iron, acetate, and methane along with …
The River Otter In Idaho: Reproductive And Population Parameters And Liver Concentrations Of Environmental Contaminants, Gina Diggs
Boise State University Theses and Dissertations
To obtain current data on the North American river otter (Lontra canadensis) population in Idaho, licensed trappers were mandated to surrender river otter carcasses through provisions of the Idaho Department of Fish and Game’s mandatory harvest report. Throughout the 2002-2003 and 2003-2004 trapping seasons, 237 river otter carcasses were collected. Necropsies were performed to assess age and sex, general body condition, reproductive rates, and concentrations of environmental contaminants in the livers. Reproductive rates were determined by counting corpora lutea and blastocysts in female river otters. Livers were dissected and concentrations of environmental contaminants were determined for the following …
Impacts Of Wind Energy Development On Breeding Buteo Hawks In The Columbia Plateau Ecoregion, Patrick Shea Kolar
Impacts Of Wind Energy Development On Breeding Buteo Hawks In The Columbia Plateau Ecoregion, Patrick Shea Kolar
Boise State University Theses and Dissertations
Post-construction raptor fatality and nest monitoring is typically conducted at wind energy projects nationwide. However, pre- and post-construction surveys may fail to locate all breeding pairs and most studies at individual wind projects lack the necessary sample size or survey design to assess the effects of turbines on nesting raptors after construction. To address these potential issues, I used an information-theoretic approach to examine the influence of multiple spatial and temporal variables on reproductive success, post-fledging survival, and the distribution of breeding pairs from three sympatric Buteo species in the Columbia Plateau Ecoregion (CPE). Although the probability of detecting breeding …
A Framework For Understanding Noise Impacts On Wildlife: An Urgent Conservation Priority, Clinton D. Francis, Jesse R. Barber
A Framework For Understanding Noise Impacts On Wildlife: An Urgent Conservation Priority, Clinton D. Francis, Jesse R. Barber
Biology Faculty Publications and Presentations
Anthropogenic noise is an important environmental stressor that is rapidly gaining attention among biologists, resource managers, and policy makers. Here we review a substantial literature detailing the impacts of noise on wildlife and provide a conceptual framework to guide future research. We discuss how several likely impacts of noise exposure have yet to be rigorously studied and outline how behavioral responses to noise are linked to the nature of the noise stimulus. Chronic and frequent noise interferes with animals’ abilities to detect important sounds, whereas intermittent and unpredictable noise is often perceived as a threat. Importantly, these effects can lead …
Local Recruitment And Natal Dispersal Distances Of American Kestrels, Karen Steenhof, Julie A. Heath
Local Recruitment And Natal Dispersal Distances Of American Kestrels, Karen Steenhof, Julie A. Heath
Biology Faculty Publications and Presentations
Variation in recruitment patterns and dispersal behavior can have important consequences for population viability, genetic structure, and rates of evolutionary change. From 1992 to 2006 we studied a marked population of American Kestrels (Falco sparverius) nesting in boxes in southwestern Idaho to identify factors that affect local recruitment and natal dispersal distances. A low proportion (4%) of locally produced kestrels (n = 2180) returned to nest in study area boxes. Offspring of locally produced individuals were 3.1 times more likely to return than offspring of parents that did not hatch in study area boxes and, independent of …
Proteolytic Cleavage Of Apolipoprotein E4 As The Keystone For The Heightened Risk Associated With Alzheimer’S Disease, Troy T. Rohn
Proteolytic Cleavage Of Apolipoprotein E4 As The Keystone For The Heightened Risk Associated With Alzheimer’S Disease, Troy T. Rohn
Biology Faculty Publications and Presentations
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by microscopic lesions consisting of beta-amyloid plaques and neurofibrillary tangles (NFTs). The majority of cases are defined as sporadic and are likely caused by a combination of both genetic and environmental factors. Of the genetic risk factors identified, the 34 kDa protein, apolipoprotein (apo) E4, is of significant importance as APOE4 carriers account for 65%–80% of all AD cases. Although apoE4 plays a normal role in lipoprotein transport, how it contributes to AD pathogenesis is currently unknown. One potential mechanism by which apoE4 contributes to disease risk is its propensity to …
Safeguarding Forensic Dna Reference Samples With Nullomer Barcodes, Jayita Goswami, Michael C. Davis, Tim Andersen, Abdelkrim Alileche, Greg Hampikian
Safeguarding Forensic Dna Reference Samples With Nullomer Barcodes, Jayita Goswami, Michael C. Davis, Tim Andersen, Abdelkrim Alileche, Greg Hampikian
Biology Faculty Publications and Presentations
Unintended transfer of biological material containing DNA is a concern to all laboratories conducting PCR analysis. While forensic laboratories have protocols in place to reduce the possibility of contaminating casework samples, there is no way to detect when a reference sample is mislabeled as evidence, or contaminates a forensic sample. Thus there is public concern regarding the safeguarding of DNA submitted to crime labs. We demonstrate a method of introducing an internal amplification control to reference samples, in the form of a nullomer barcode which is based upon sequences absent or rare from publically accessible DNA databases. The detection of …
Increase In Acc Oxidase Levels And Activities During Paradormancy Release Of Leafy Spurge (Euphorbia Esula) Buds, Wun S. Chao, Marcelo Serpe, Jeffrey C. Suttle, Ying Jia
Increase In Acc Oxidase Levels And Activities During Paradormancy Release Of Leafy Spurge (Euphorbia Esula) Buds, Wun S. Chao, Marcelo Serpe, Jeffrey C. Suttle, Ying Jia
Biology Faculty Publications and Presentations
The plant hormone ethylene is known to affect various developmental processes including dormancy and growth. Yet, little information is available about the role of ethylene during paradormancy release in underground adventitious buds of leafy spurge. In this study, we examined changes in ethylene evolution and the ethylene biosynthetic enzyme ACC oxidase following paradormancy release (growth induction). Our results did not show an obvious increase in ethylene during bud growth. However, when buds were incubated with 1 mM ACC, ethylene levels were higher in growing than non-growing buds, suggesting that the levels of ACC oxidase increased in growing buds. Real-time qPCR …
Examining New Phylogenetic Markers To Uncover The Evolutionary History Of Early-Diverging Fungi: Comparing Mcm7, Tsr1 And Rrna Genes For Single- And Multi-Gene Analyses Of The Kickxellomycotina, Eric D. Tretter, E. M. Johnson, Yan Wang, Prasanna Kandel, Merlin M. White
Examining New Phylogenetic Markers To Uncover The Evolutionary History Of Early-Diverging Fungi: Comparing Mcm7, Tsr1 And Rrna Genes For Single- And Multi-Gene Analyses Of The Kickxellomycotina, Eric D. Tretter, E. M. Johnson, Yan Wang, Prasanna Kandel, Merlin M. White
Biology Faculty Publications and Presentations
The recently recognised protein-coding genes MCM7 and TSR1 have shown significant promise for phylogenetic resolution within the Ascomycota and Basidiomycota, but have remained unexamined within other fungal groups (except for Mucorales). We designed and tested primers to amplify these genes across early-diverging fungal clades, with emphasis on the Kickxellomycotina, zygomycetous fungi with characteristic flared septal walls forming pores with lenticular plugs. Phylogenetic tree resolution and congruence with MCM7 and TSR1 were compared against those inferred with nuclear small (SSU) and large subunit (LSU) rRNA genes. We also combined MCM7 and TSR1 data with the rDNA data to …
Evaluating The Effects Of Fungicides And Other Pesticides On Non-Target Gut Fungi And Their Aquatic Insect Hosts, Emma R. Wilson
Evaluating The Effects Of Fungicides And Other Pesticides On Non-Target Gut Fungi And Their Aquatic Insect Hosts, Emma R. Wilson
Boise State University Theses and Dissertations
Pesticides are widespread and have been long used to combat the attack and destruction of crops. Fungicides have been used to prevent the establishment of many fungal pathogens, yet little is known about the impacts of fungicides on non-target fungi. With these considerations, it was predicted that trichomycetes, or gut fungi, a group of symbiotic fungi associated with aquatic macroinvertebrates and other arthropods, might be a candidate system to study because of the intimate association with their hosts. Field and laboratory studies were initiated to assess non-target impacts of fungicides on gut fungi. Field surveys were conducted on four streams …
Bromus Tectorum Litter Alters Photosynthetic Characteristics Of Biological Soil Crusts From A Semiarid Shrubland, Marcelo D. Serpe, Eric Roberts, David J. Eldridge, Roger Rosentreter
Bromus Tectorum Litter Alters Photosynthetic Characteristics Of Biological Soil Crusts From A Semiarid Shrubland, Marcelo D. Serpe, Eric Roberts, David J. Eldridge, Roger Rosentreter
Biology Faculty Publications and Presentations
Invasion by the exotic annual grass Bromus tectorum has increased the cover and connectivity of fine litter in the sagebrush steppes of western North America. This litter tends to cover biological soil crusts, which could affect their metabolism and growth. To investigate this possible phenomenon, biological soil crusts dominated by either the moss Bryum argenteum or the lichen Diploschistes muscorum were covered with B.tectorum litter (litter treatment) or left uncovered (control treatment) and exposed to natural field conditions. After periods of five and ten months, we removed the litter and compared the photosynthetic performance of biological soil crusts …
Human Disturbance And Stage-Specific Habitat Requirements Influence Snowy Plover Site Occupancy During The Breeding Season, Alyson F. Webber, Julie A. Heath, Richard A. Fischer
Human Disturbance And Stage-Specific Habitat Requirements Influence Snowy Plover Site Occupancy During The Breeding Season, Alyson F. Webber, Julie A. Heath, Richard A. Fischer
Biology Faculty Publications and Presentations
Habitat use has important consequences for avian reproductive success and survival. In coastal areas with recreational activity, human disturbance may limit use of otherwise suitable habitat. Snowy plovers Charadrius nivosus have a patchy breeding distribution along the coastal areas on the Florida Panhandle, USA. Our goal was to determine the relative effects of seasonal human disturbance and habitat requirements on snowy plover habitat use. We surveyed 303 sites for snowy plovers, human disturbance, and habitat features between January and July 2009 and 2010. We made multiple visits during three different sampling periods that corresponded to snowy plover breeding: pre-breeding, incubation, …
A Pharm-Ecological Perspective Of Terrestrial And Aquatic Plant-Herbivore Interactions, Jennifer Sorensen Forbey, M. Denise Dearing, Elisabeth M. Gross, Colin M. Orians, Erik E. Sotka, William J. Foley
A Pharm-Ecological Perspective Of Terrestrial And Aquatic Plant-Herbivore Interactions, Jennifer Sorensen Forbey, M. Denise Dearing, Elisabeth M. Gross, Colin M. Orians, Erik E. Sotka, William J. Foley
Biology Faculty Publications and Presentations
We describe some recent themes in the nutritional and chemical ecology of herbivores and the importance of a broad pharmacological view of plant nutrients and chemical defenses that we integrate as “Pharm-ecology”. The central role that dose, concentration, and response to plant components (nutrients and secondary metabolites) play in herbivore foraging behavior argues for broader application of approaches derived from pharmacology to both terrestrial and aquatic plant-herbivore systems. We describe how concepts of pharmacokinetics and pharmacodynamics are used to better understand the foraging phenotype of herbivores relative to nutrient and secondary metabolites in food. Implementing these concepts into the field …
The Triggering Receptor Expressed On Myeloid Cells 2: “Trem-Ming” The Inflammatory Component Associated With Alzheimer's Disease, Troy T. Rohn
Biology Faculty Publications and Presentations
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive loss of memory and cognitive skills. Although much attention has been devoted concerning the contribution of the microscopic lesions, senile plaques, and neurofibrillary tangles to the disease process, inflammation has long been suspected to play a major role in the etiology of AD. Recently, a novel variant in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) has been identified that has refocused the spotlight back onto inflammation as a major contributing factor in AD. Variants in TREM2 triple one's risk of developing late-onset AD. …
Phytochemistry Predicts Habitat Selection By An Avian Herbivore At Multiple Spatial Scales, Graham G. Frye, John W. Connelly, David D. Musil, Jennifer S. Forbey
Phytochemistry Predicts Habitat Selection By An Avian Herbivore At Multiple Spatial Scales, Graham G. Frye, John W. Connelly, David D. Musil, Jennifer S. Forbey
Biology Faculty Publications and Presentations
Animal habitat selection is a process that functions at multiple, hierarchically structured spatial scales. Thus multi-scale analyses should be the basis for inferences about factors driving the habitat selection process. Vertebrate herbivores forage selectively on the basis of phytochemistry, but few studies have investigated the influence of selective foraging (i.e., fine-scale habitat selection) on habitat selection at larger scales. We tested the hypothesis that phytochemistry is integral to the habitat selection process for vertebrate herbivores. We predicted that habitats selected at three spatial scales would be characterized by higher nutrient concentrations and lower concentrations of plant secondary metabolites (PSMs) than …
Matrix Gla Protein Reinforces Angiogenic Resolution, Bikram Sharma, Allan R. Albig
Matrix Gla Protein Reinforces Angiogenic Resolution, Bikram Sharma, Allan R. Albig
Biology Faculty Publications and Presentations
Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear. Utilizing a mouse MGP knockout model we found that MGP suppresses angiogenic sprouting from mouse aorta restricts microvascular density in cardiac and skeletal muscle, and is an endogenous inhibitor of tumor angiogenesis. Similarly, morpholino based knockdown of MGP in zebrafish embryos caused a progressive loss of luminal structures in intersegmental vessels, a phenotype reminiscent of Dll4/Notch inhibition. Accordingly, MGP suppressed Notch-dependent Hes-1 promoter activity and expression of …
Caspase-Cleaved Glial Fibrillary Acidic Protein Within Cerebellar White Matter Of The Alzheimer's Disease Brain, Troy T. Rohn, Lindsey W. Catlin, Wayne W. Poon
Caspase-Cleaved Glial Fibrillary Acidic Protein Within Cerebellar White Matter Of The Alzheimer's Disease Brain, Troy T. Rohn, Lindsey W. Catlin, Wayne W. Poon
Biology Faculty Publications and Presentations
Although the cerebellum is generally thought of as an area spared of Alzheimer's disease (AD) pathology, recent evidence suggests that balance and mobility dysfunction may be magnified in affected individuals. In the present study, we sought to determine the degree of pathological changes within the cerebellum utilizing an antibody that specifically detects caspase-cleaved GFAP within degenerating astrocytes. Compared to control subjects, application of this antibody, termed the GFAP caspase-cleavage product (GFAPccp) antibody, revealed widespread labeling in cerebellar white matter with little staining observed in grey matter. Staining was observed within damaged astrocytes, was often localized near blood vessels and co-localized …