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Full-Text Articles in Life Sciences
Clinical Significance Of Interleukin (Il)-6 In Cancer Metastasis To Bone: Potential Of Anti-Il-6 Therapies, Ken Tawara, Julia T. Oxford, Cheryl L. Jorcyk
Clinical Significance Of Interleukin (Il)-6 In Cancer Metastasis To Bone: Potential Of Anti-Il-6 Therapies, Ken Tawara, Julia T. Oxford, Cheryl L. Jorcyk
Biology Faculty Publications and Presentations
Metastatic events to the bone occur frequently in numerous cancer types such as breast, prostate, lung, and renal carcinomas, melanoma, neuroblastoma, and multiple myeloma. Accumulating evidence suggests that the inflammatory cytokine interleukin (IL)-6 is frequently upregulated and is implicated in the ability of cancer cells to metastasize to bone. IL-6 is able to activate various cell signaling cascades that include the STAT (signal transducer and activator of transcription) pathway, the PI3K (phosphatidylinositol-3 kinase) pathway, and the MAPK (mitogen-activated protein kinase) pathway. Activation of these pathways may explain the ability of IL-6 to mediate various aspects of normal and pathogenic bone …