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Caspase-Cleaved Tar Dna-Binding Protein-43 In Parkinson’S Disease And Dementia With Lewy Bodies, Polina Kokoulina, Troy T. Rohn
Caspase-Cleaved Tar Dna-Binding Protein-43 In Parkinson’S Disease And Dementia With Lewy Bodies, Polina Kokoulina, Troy T. Rohn
Biology Faculty Publications and Presentations
Background: TAR DNA-binding protein-43 (TDP-43) proteinopathies are classified based upon the extent of modified TDP-43 and include a growing number of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with ubiquitin immunoreactive, tau-negative inclusions (FTLD-U) and FTLD with motor neuron disease (FTLD-MND). Objective: The purpose of the study was to examine whether proteolytic modifications of TDP-43 are a relevant finding in Parkinson’s disease (PD) and dementia with Lewy Bodies (DLB). Methods: A novel site-directed caspase-cleavage antibody, termed TDP caspase-cleavage product antibody (TDPccp), was utilized based upon a known caspase-3 cleavage consensus site within TDP-43 at position 219. …