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Full-Text Articles in Life Sciences
An Amino-Terminal Fragment Of Apolipoprotein E4 Leads To Behavioral Deficits, Increased Phf-1 Immunoreactivity, And Mortality In Zebrafish, Madyson M. Mccarthy, Makenna J. Hardy, Saylor E. Leising, Alex M. Lafollette, Erica S. Stewart, Amelia S. Cogan, Tanya Sanghal, Katie Matteo, Jonathon C. Reeck, Julia T. Oxford, Troy T. Rohn
An Amino-Terminal Fragment Of Apolipoprotein E4 Leads To Behavioral Deficits, Increased Phf-1 Immunoreactivity, And Mortality In Zebrafish, Madyson M. Mccarthy, Makenna J. Hardy, Saylor E. Leising, Alex M. Lafollette, Erica S. Stewart, Amelia S. Cogan, Tanya Sanghal, Katie Matteo, Jonathon C. Reeck, Julia T. Oxford, Troy T. Rohn
Biology Faculty Publications and Presentations
Although the increased risk of developing sporadic Alzheimer’s disease (AD) associated with the inheritance of the apolipoprotein E4 (APOE4) allele is well characterized, the molecular underpinnings of how ApoE4 imparts risk remains unknown. Enhanced proteolysis of the ApoE4 protein with a toxic-gain of function has been suggested and a 17 kDa amino-terminal ApoE4 fragment (nApoE41-151) has been identified in post-mortem human AD frontal cortex sections. Recently, we demonstrated in vitro, exogenous treatment of nApoE41-151 in BV2 microglial cells leads to uptake, trafficking to the nucleus and increased expression of genes associated with cell toxicity …
Genetic Testing: Should I Get Tested For Alzheimer’S Risk?, Troy Rohn
Genetic Testing: Should I Get Tested For Alzheimer’S Risk?, Troy Rohn
Biology Faculty Publications and Presentations
Genetic testing is available to people who want to know if they carry a variant of a gene that confers susceptibility for Alzheimer’s. But knowing whether to get tested is hard.
Early-Onset Alzheimer’S: Should You Worry?, Troy Rohn
Early-Onset Alzheimer’S: Should You Worry?, Troy Rohn
Biology Faculty Publications and Presentations
You have forgotten where you put your car keys, or you can’t seem to remember the name of your colleague you saw in the grocery store the other day. You fear the worst, that maybe these are signs of Alzheimer’s disease.