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Role Of Monocyte Chemoattractant Protein-1 During Liver Regeneration, Stephanie Wyler
Role Of Monocyte Chemoattractant Protein-1 During Liver Regeneration, Stephanie Wyler
Boise State University Theses and Dissertations
Liver regeneration is a complex process that requires the coordinated expression of cytokines and growth factors. One well-studied model of liver regeneration is partial hepatectomy (PH), in which removal of 70% of the liver initiates compensatory hepatocyte proliferation. PH-induced liver regeneration requires the activation of resident macrophages (Kupffer cells), which produce cytokines that drive hepatocyte proliferation. Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that is known to activate macrophages and recruit monocytes during tissue injury. The goal of this study was to determine how MCP-1 contributes to macrophage activation during liver regeneration. Results indicate that hepatic and plasma MCP-1 levels …