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Full-Text Articles in Life Sciences
A Common Endocrine Signature Marks The Convergent Evolution Of An Elaborate Dance Display In Frogs, Nigel K. Anderson, Eric R. Schuppe, K. V. Gururaja, Lisa A. Mangiamele, Juan Carlos Cusi Martinez, H. Priti, Rudolf Von May, Doris Preininger, Matthew J. Fuxjager
A Common Endocrine Signature Marks The Convergent Evolution Of An Elaborate Dance Display In Frogs, Nigel K. Anderson, Eric R. Schuppe, K. V. Gururaja, Lisa A. Mangiamele, Juan Carlos Cusi Martinez, H. Priti, Rudolf Von May, Doris Preininger, Matthew J. Fuxjager
Biological Sciences: Faculty Publications
Unrelated species often evolve similar phenotypic solutions to the same environmental problem, a phenomenon known as convergent evolution. But how do these common traits arise? We address this question from a physiological perspective by assessing how convergence of an elaborate gestural display in frogs (foot-flagging) is linked to changes in the androgenic hormone systems that underlie it. We show that the emergence of this rare display in unrelated anuran taxa is marked by a robust increase in the expression of androgen receptor (AR) messenger RNA in the musculature that actuates leg and foot movements, but we find no evidence of …
Androgen Receptor, Although Not A Specific Marker For, Is A Novel Target To Suppress Glioma Stem Cells As A Therapeutic Strategy For Glioblastoma, Nan Zhao, Fei Wang, Shaheen Ahmed, Kan Liu, Chi Zhang, Sahara J. Cathcart, Dominick J. Dimaio, Michael Punsoni, Bingjie Guan, Ping Zhou, Shuo Wang, Surinder K. Batra, Tatiana Bronich, Tom K. Hei, Chi Lin, Chi Zhang
Androgen Receptor, Although Not A Specific Marker For, Is A Novel Target To Suppress Glioma Stem Cells As A Therapeutic Strategy For Glioblastoma, Nan Zhao, Fei Wang, Shaheen Ahmed, Kan Liu, Chi Zhang, Sahara J. Cathcart, Dominick J. Dimaio, Michael Punsoni, Bingjie Guan, Ping Zhou, Shuo Wang, Surinder K. Batra, Tatiana Bronich, Tom K. Hei, Chi Lin, Chi Zhang
School of Biological Sciences: Faculty Publications
Targeting androgen receptor (AR) has been shown to be promising in treating glioblastoma (GBM) in cell culture and flank implant models but the mechanisms remain unclear. AR antagonists including enzalutamide are available for treating prostate cancer patients in clinic and can pass the blood–brain barrier, thus are potentially good candidates for GBM treatment but have not been tested in GBM orthotopically. Our current studies confirmed that in patients, a majority of GBM tumors overexpress AR in both genders. Enzalutamide inhibited the proliferation of GBM cells both in vitro and in vivo. Although confocal microscopy demonstrated that AR is expressed but …