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Full-Text Articles in Life Sciences
Trichomycetes From Lentic And Lotic Aquatic Habitats In Ontario, Canada, D. B. Strongman, Merlin M. White
Trichomycetes From Lentic And Lotic Aquatic Habitats In Ontario, Canada, D. B. Strongman, Merlin M. White
Biology Faculty Publications and Presentations
Fungi and protists make up an ecological group, trichomycetes, that inhabit the guts of invertebrates, mostly aquatic insects. Trichomycetes are reported herein from arthropods collected in lotic habitats (fast flowing streams) and lentic environments (ponds, ditches, seeps, and lakes) from 11 sites in Algonquin Park and 6 other sites in Ontario, Canada. Thirty-two trichomycete species were recovered, including 7 new species: Legeriomyces algonquinensis, Legeriosimilis leptocerci, Legeriosimilis whitneyi and Paramoebidium umbonatum are described from mayfly nymphs (Ephemeroptera); Pennella digitata and Glotzia incilis from black fly and midge larvae (Diptera), respectively; and Arundinula opeongoensis from a crayfish (Crustacea). Legeriomyces rarus Lichtw. & …
Ambient Temperature Influences Diet Selection And Physiology Of An Herbivorous Mammal, Neotoma Albigula, M. D. Dearing, Jennifer S. Forbey, J. D. Mclister, L. Santos
Ambient Temperature Influences Diet Selection And Physiology Of An Herbivorous Mammal, Neotoma Albigula, M. D. Dearing, Jennifer S. Forbey, J. D. Mclister, L. Santos
Biology Faculty Publications and Presentations
The whitethroat woodrat (Neotoma albigula) eats juniper (Juniperus monosperma), but the amount of juniper in its diet varies seasonally. We tested whether changes in juniper consumption are due to changes in ambient temperature and what the physiological consequences of consuming plant secondary compounds (PSCs) at different ambient temperatures might be. Woodrats were acclimated to either 20ºC or 28ºC. Later, they were given two diets to choose from (50% juniper and a nontoxic control) for 7 d. Food intake, resting metabolic rate (RMR), and body temperature (Tb) were measured over the last 2 d. Woodrats at 28ºC …
Caspase-Cleaved Tar Dna Binding Protein-43 Is A Major Pathological Finding In Alzheimer’S Disease, Troy T. Rohn
Caspase-Cleaved Tar Dna Binding Protein-43 Is A Major Pathological Finding In Alzheimer’S Disease, Troy T. Rohn
Biology Faculty Publications and Presentations
The TAR DNA binding protein-43 (TDP-43) has been identified as a major constituent of inclusions found in frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). To determine a possible role for TDP-43 in Alzheimer’s disease (AD), a site-directed caspase-cleavage antibody to TDP-43 based upon a known caspase-3 cleavage consensus site within TDP-43 at position D219 was designed. In vitro, this antibody labeled the predicted 25 kDa caspase-cleavage fragment of TDP-43 without labeling full-length TDP-43 following digestion of recombinant TDP-43 with caspase-3 or treatment of Hela cells with staurosporine. Application of this antibody in postmortem brain sections …
Lack Of Pathology In A Triple Transgenic Mouse Model Of Alzheimer’S Disease After Overexpression Of The Anti-Apoptotic Protein Bcl-2, Troy T. Rohn, Veera Vyas, Tatiana Hernandez-Estrada, Kathryn E. Nichol, Lori-Ann Christie, Elizabeth Head
Lack Of Pathology In A Triple Transgenic Mouse Model Of Alzheimer’S Disease After Overexpression Of The Anti-Apoptotic Protein Bcl-2, Troy T. Rohn, Veera Vyas, Tatiana Hernandez-Estrada, Kathryn E. Nichol, Lori-Ann Christie, Elizabeth Head
Biology Faculty Publications and Presentations
Alzheimer’s disease (AD) is characterized by the accumulation of plaques containing ß-amyloid (Aß) and neurofibrillary tangles (NFTs) consisting of modified tau. Although Aß deposition is thought to precede the formation of NFTs in AD, the molecular steps connecting these two pathologies is not known. Previous studies have suggested that caspase activation plays an important role in promoting the pathology associated with AD. To further understand the contribution of caspases in disease progression, a triple transgenic Alzheimer’s mouse model overexpressing the anti-apoptotic protein Bcl-2 was generated. Here we show that overexpression of Bcl-2 limited caspase-9 activation and reduced the caspase cleavage …