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Articles 1 - 12 of 12
Full-Text Articles in Life Sciences
Human Motion Detection Evaluated Through An Evoked Cortical Potential Frequency Spectrum, Howard E. Painter
Human Motion Detection Evaluated Through An Evoked Cortical Potential Frequency Spectrum, Howard E. Painter
USF Tampa Graduate Theses and Dissertations
Electrical potentials were recorded from scalp of normal male subjects while they were viewing continuously moving sinusoidal gratings. Responses from the occipital cortex were amplified, digitized, stored and then transformed from the time domain to the frequency domain using a microcomputer based Fast Fourier Transform algorithm. High frequency components (Beta Activity) of the resulting power spectrum were analyzed for evidence on neural generators (electrical sources) in the striate cortex driven presumably by transient-cells (Y-cells or Magnocellular) responding to the continuously moving grating. Several stimulus parameters were examined: angular velocity, spatial frequency, direction (orientation), color, and intensity. A16 Hz component of …
Targeting Bet Proteins Downregulates Mir-33a To Promote Synergy With Pim Inhibitors In Cmml, Christopher T. Letson
Targeting Bet Proteins Downregulates Mir-33a To Promote Synergy With Pim Inhibitors In Cmml, Christopher T. Letson
USF Tampa Graduate Theses and Dissertations
Chronic Myelomonocytic Leukemia (CMML) is a rare myeloid malignancy with a dismal prognosis and no therapeutic options which are capable of altering the natural course of the disease. There remains a significant need for novel therapies that are able to meaningfully improve patient outcomes. In this study we explore the effectiveness of Bromodomain and Extra-Terminal domain protein inhibitor (BETi) combinations in CMML. Preclinical studies in myeloid neoplasms have demonstrated efficacy of BETi. However, BETi demonstrate poor single agent activity in clinical trials. Several studies suggest that combinations with other anti-cancer inhibitors may enhance the efficacy of BETi. To nominate BETi …
Patterns In Biodiversity And Community Assemblage In Macrofaunal Fouling Communities On Tampa Bay Floating Docks, Cassidy C. Bell
Patterns In Biodiversity And Community Assemblage In Macrofaunal Fouling Communities On Tampa Bay Floating Docks, Cassidy C. Bell
USF Tampa Graduate Theses and Dissertations
Understanding biodiversity trends of highly disturbed urban landscapes is essential as anthropogenic factors continue to drive global biodiversity loss. Within marine ecosystems, macrofaunal fouling communities, aggregations of epibenthic invertebrates that colonize human-made structures, represent an ecologically important subset of urban coastlines. Tampa Bay is a highly urbanized estuary in Florida, USA, and is home to the state’s largest port, Port Tampa Bay. This makes the bay a prime site for the introduction of new species, with many organisms either considered invasive or cryptogenic, their origins left unclear. Many factors may contribute to the communities that form on urban structures including …
Hurricanes And Tropical Storms’ Impact On Water Quality In Lake Okeechobee, Florida, Daniela Vasquez Diaz
Hurricanes And Tropical Storms’ Impact On Water Quality In Lake Okeechobee, Florida, Daniela Vasquez Diaz
USF Tampa Graduate Theses and Dissertations
Hurricanes are natural events with catastrophic outcomes, while climate change's effects on their intensity and frequency remain discussed. However, it is crucial to analyze these through models and statistics to understand their behavior and impact on the basins. Particularly in lakes on tropical coasts since disruptive events such as hurricanes tend to be highly affected. Lake Okeechobee is a unique lake located in Florida and one of the largest freshwater lakes. The lake and some of its significant stations are the locations chosen to perform the investigation. The main focus of the investigation is determining the effect that hurricanes have …
Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation And Progression, Janine M. Deblasi
Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation And Progression, Janine M. Deblasi
USF Tampa Graduate Theses and Dissertations
NRF2 is a redox-responsive transcription factor the directs the antioxidant program and several critical metabolic processes. Mutations in NRF2 or its negative regulator KEAP1 occur in up to one third of non-small cell lung cancers (NSCLCs) and are often associated with resistance to therapy and poor outcomes. In the present studies, murine alleles of the Keap1 and Nrf2 mutations found in human NSCLC were developed and I comprehensively investigated their impact on tumor initiation and progression. I observed that chronic Nrf2 stabilization by Keap1 loss-of-function or Nrf2 activating mutation was not sufficient to cause lung tumor initiation, even when p53 …
Resource Recovery From Crew Metabolic Wastes In Lunar And Martian Habitats: Reuse Of Effluent From An Anaerobic Membrane Bioreactor Treating Fecal Organic Matter As Fertilizer Source For Plants, Alexandra A. Smith
USF Tampa Graduate Theses and Dissertations
As humans set their sights on exploration of the Moon and Mars human focused challenges like providing potable water, supplying nutritious food to the astronaut crew, and managing their waste present themselves. There are no readily available resources on the Moon and Mars, therefore nothing should be considered unusable including the organic wastes (i.e., feces and urine) produced by the crew. Fecal matter is not currently recycled and is treated as solid waste. After collection, it is discarded out of the International Space Station where it is incinerated upon re-entry. This approach will not work on the Moon’s surface. There …
Examination Of Microplastics And Organic Contaminants In Tampa Bay’S Eastern Oyster (Crassostrea Virginica) Through Visual And Chemical Analysis, Andrea Murray
USF Tampa Graduate Theses and Dissertations
Microplastic pollution is an increasingly alarming concern with widespread global distribution in aquatic environments. Filter feeding organisms such as bivalves, have a heightened risk of microplastic ingestion through free floating particulates in the water. This can lead to bioaccumulation moving up through trophic levels to apex predators and humans. Spatial and temporal differences in microplastic abundance were evaluated in the Eastern Oyster, Crassostrea virginica, at six sites within Tampa Bay. Oyster tissue was digested using 30% hydrogen peroxide (H2O2) and microplastics were quantified using Nile Red dye and fluorescent particle excitement. A total of 3025 microplastics were found throughout six …
Statistical Analysis Of Ribonucleotide Incorporation In Human Cells, Tejasvi Channagiri
Statistical Analysis Of Ribonucleotide Incorporation In Human Cells, Tejasvi Channagiri
USF Tampa Graduate Theses and Dissertations
During the DNA replication process, ribonucleotides, the building blocks of RNA, may be occasionally incorporated in the newly synthesized DNA. DNA is primarily composed of deoxyribonucleotides and there exist cellular mechanisms for removing ribonucleotides from DNA, which may point towards ribonucleotide incorporation being a replication error. Further, an excess of these ribonucleotides in the genome has been known to lead to genomic instability and has been implicated in human diseases. However, there are also hypotheses that suggest that ribonucleotides may be beneficial in certain circumstances. In this study we examine ribonucleotide incorporation in the human genome in several human cell …
The Role Of The Dna Helicase Rrm3 Under Replication Stress, Julius Muellner
The Role Of The Dna Helicase Rrm3 Under Replication Stress, Julius Muellner
USF Tampa Graduate Theses and Dissertations
DNA replication needs to be strictly monitored to ensure proper duplication of the genome. During DNA synthesis, the DNA replication machinery encounters multiple obstacles such as incorrect dNTP incorporation, RNA-DNA hybrids, modification of DNA nucleobases, collision with the transcription-replication machinery. These endogenous and exogenous sources of DNA damage may result in single-strand breaks (SSBs) and double-strand DNA breaks (DSBs), thereby impeding fork progression. To prevent stalling of DNA synthesis a multitude of DNA repair pathways are specifically designed to deal with these kinds of blockages. One of the proteins involved in ensuring DNA replication fork progression is the DNA helicase …
Histone Deacetylase 8 Is A Novel Therapeutic Target For Mantle Cell Lymphoma And Preserves Natural Killer Cell Cytotoxic Function, January M. Watters
Histone Deacetylase 8 Is A Novel Therapeutic Target For Mantle Cell Lymphoma And Preserves Natural Killer Cell Cytotoxic Function, January M. Watters
USF Tampa Graduate Theses and Dissertations
This study demonstrates for the first time that HDAC8 function is critical for MCL survival, and abrogating its activity in human primary NK cells does not interfere with NK IgG antibody directed ADCC therapies ex vivo. Human NK cells, isolated from healthy donors, are highly resistant to HDAC8 inhibitor treatment with PCI-34051. Even at the highest concentration, 20uM, no toxicity was observed. Conversely, MCL cell lines representative of the aggressive MCL subtype, classical MCL, were especially sensitive to PCI-34051, an HDAC8 selective inhibitor, treatment. Blocking HDAC8 activity and/or abrogating expression through shRNA silencing induced significant DNA damage, hyperacetylation of SMC3, …
Comparing Mortality In Response To Simulated Climate Change In The Harvester Ant, Pogonomyrmex Badius, And The Fire Ant, Solenopsis Invicta, Haley Depner
USF Tampa Graduate Theses and Dissertations
With the rapid transport of plants, produce, and goods out of its South American home, the fire ant, Solenopsis invicta, has invaded continents on a global scale. In the United States alone, S. invicta is responsible for an estimated $1 billion in damages annually. In contrast to the invasive fire ant, Florida’s native harvester ant, Pogonomyrmex badius, is a keystone seed disperser, providing seed relocation benefits to Florida’s sandhill wildfire-adapted habitats. Seed relocation reduces seedling competition for nutrients with the parent plant, reduces predation of seeds by rodents, increases nutrient loads associated with ant mound soils, and protects seeds from …
Diatom Diversity And Functional Groups In 72 Florida Lakes: Assessing Ecological Changes For Improved Protection And Management, Francesca M. Lauterman
Diatom Diversity And Functional Groups In 72 Florida Lakes: Assessing Ecological Changes For Improved Protection And Management, Francesca M. Lauterman
USF Tampa Graduate Theses and Dissertations
Florida lakes are diverse ecosystems and are an important part of the state's biodiversity and ecosystem services. As human population and development increase across the state, many lakes have been documented as nutrient impaired and are unable to maintain essential ecological functions. In this study, diatom diversity and functional groups in 72 Florida lakes were assessed for their relationships with associated water-quality data. Common alpha diversity indices, including Shannon-Weiner Index, the Gini-Simpson Index, and Hill’s numbers were utilized to measure trends in diatom communities, while the relationships between diatom lifeform characteristics and environmental data were explored using multivariate methods and …