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Full-Text Articles in Life Sciences
The Effects Of Ethynodiol Diacetate On Epinephrine-Treated Glial-Derived Cells, Jesse D. Hunt
The Effects Of Ethynodiol Diacetate On Epinephrine-Treated Glial-Derived Cells, Jesse D. Hunt
Theses and Dissertations
Neuroprotective agents, including specific hormones, may play a role in preventing cellular damage following an ischemic event or brain injury. Astrocytes are specialized glial cells within the central nervous system that play roles in synapse development, blood flow regulation, extracellular homeostasis, synapse function, energy and metabolism (Sofroniew and Vinters, 2009). Research using astrocytes in cell viability studies can be beneficial in deepening our understanding of specific neuroprotective effects of various steroid hormones including progesterone. Progesterone has been shown to have neuroprotective capabilities in the central nervous system (Scarpin et ah, 2009). Although progesterone shows great therapeutic potential, effects of the …
The Involvement Of Progesterone In Glial Cell Viability, Tracee L. Guthrie
The Involvement Of Progesterone In Glial Cell Viability, Tracee L. Guthrie
Theses and Dissertations
We studied the effects of ethynodiol diacetate on the viability of hydrogen peroxide stressed glial cells. We wanted to determine the extent in which varying concentration of ethynodiol diacetate affect cell viability of cultured glial cells from hydrogen peroxide toxicity. Based on previous studies, we predicted that the viability of hydrogen peroxide-stressed cells will increase with the presence of the progesterone, ethynodiol diacetate, and that cell viability will increase with increasing concentration of ethynodiol diacetate. Glial cells of 1x10° cells/well were introduced into a 96-well plate and allowed to grow for 24 hours in an incubator at 37°C and 5% …