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Full-Text Articles in Life Sciences
Central Precocious Puberty Alters The Mammary Gland Epithelial Landscape In Female Rats, Alina M. Hamilton
Central Precocious Puberty Alters The Mammary Gland Epithelial Landscape In Female Rats, Alina M. Hamilton
Theses and Dissertations
Precocious puberty (PP) is a serious endocrine disorder associated with an increased risk for development of breast cancer (BC) later in life. However, the lack of a strong in vivo model has made it difficult to study this relationship. Our group has established manganese (Mn) as a non-toxic activator of the pubertal process. Recently we demonstrated that Mn-induced precocious puberty (MnPP) accelerates E2-regulated mammary gland (MG) development in prepubertal female rats, resulting in persistent proliferation and adult hyperplasia. Using this model, I demonstrate that precocious puberty alters steroidal regulation of proliferation in both the prepubertal and adult virgin MG, altering …
Integrative Analysis To Evaluate Similarity Between Brcaness Tumors And Brca Tumors, Weston Reed Bodily
Integrative Analysis To Evaluate Similarity Between Brcaness Tumors And Brca Tumors, Weston Reed Bodily
Theses and Dissertations
The term "BRCAness" is used to describe breast-cancer patients who lack a germline mutation in BRCA1 or BRCA2, yet who are believed to express characteristics similar to patients who do have a germline mutation in BRCA1 or BRCA2. Although it is hypothesized that BRCAness is related to deficiency in the homologous recombination repair (HRR) pathways, relatively little is understood about what drives BRCAness or what criteria should be used to assign patients to this category. We hypothesized that patients whose tumor carries a genomic or epigenomic aberration in BRCA1 or BRCA2 should be classified under the BRCAness category and that …
Integrative Analysis To Evaluate Similarity Between Brcaness Tumors And Brca Tumors, Weston Reed Bodily
Integrative Analysis To Evaluate Similarity Between Brcaness Tumors And Brca Tumors, Weston Reed Bodily
Theses and Dissertations
The term "BRCAness" is used to describe breast-cancer patients who lack a germline mutation in BRCA1 or BRCA2, yet who are believed to express characteristics similar to patients who do have a germline mutation in BRCA1 or BRCA2. Although it is hypothesized that BRCAness is related to deficiency in the homologous recombination repair (HRR) pathways, relatively little is understood about what drives BRCAness or what criteria should be used to assign patients to this category. We hypothesized that patients whose tumor carries a genomic or epigenomic aberration in BRCA1 or BRCA2 should be classified under the BRCAness category and that …