Life Sciences Commons^™

Enhancing The Efficacy Of Thymidylate Synthase Inhibitors By Genetic Modulation Or Pharmacological Inhibition Of Bone Marrow Derived Cells In The Tumor Stroma, Nikeya Lashanna Tisdale

Theses and Dissertations

The impact of tumor associated stromal cells in tumor formation, progression, and response to therapy has led to a paradigm shift in cancer therapy. For many years, tumors were considered as a mass consisting only of actively proliferating cancer cells and therapies were design to target these cells. However, research in the last two decades has shown that tumors are not only comprised of a heterogeneous population of neoplastic cells, but they are also comprised of and infiltrated by a heterogeneous population of non-tumor cells that contribute to tumor progression and potentially affect the efficacy of tumor-directed chemotherapies. Tumors are …

The Cranial Morphology Of The Black-Footed Ferret: A Comparison Of Wild And Captive Specimens, Tyler Antonelli

Theses and Dissertations

The black-footed ferret (Mustela nigripes), a North American mustelid species, was once found abundantly throughout the Midwest until extreme decline in prairie dogs, the black-footed ferrets primary food source, brought the species to near-extinction. This resulted in the development of the Black-Footed Ferret Recovery Program which included bringing the entire species into captivity with the intention of breeding the species back to sufficient numbers to allow for successful reintroduction. While in captivity, many components of the ferrets’ health were accounted for, but the current study aims to address the effects that captivity may have had on the cranial morphology of …

Defensive Roles And Factors That Affect The Production Of Monoterpenes In Morella Cerifera, Florence C. Anoruo

Theses and Dissertations

Plants as sessile organisms encounter myriad biotic and abiotic challenges in their habitats. Pathogen and herbivore attack are among the prominent biotic challenges that plants face in their environment. Plants respond to these attacks by using chemical compounds including monoterpenes that are constitutively and inductively produced in some plants, and stored inside glands on their leaves. Among the abiotic factors that influence the production of defense compounds, especially monoterpenes are light intensity and nutrient availability.

The objectives of this dissertation are to 1) comprehend the defensive role of monoterpenes, specifically investigating the associational defense of a non-odorous species (Ilex vomitoria) …

Interactions Between Hiv-1 Tat And Tumor Suppressor P53, Kristen Lane Spotts

Theses and Dissertations

The most well studied cancer-related gene in history, p53, is responsible for protecting the integrity of the genome. A variety of different stresses are detected by p53 and its regulators, allowing for numerous post-translational modifications that activate p53. After activation p53 can then regulate transcription of a myriad downstream targets, resulting in either cell cycle arrest or apoptosis. One of the stress signals that activates p53 is viral infection in part through the induction of type-1 interferon. However some viruses, like the DNA tumor viruses have evolved factors capable of binding to p53 and inhibiting its ability to regulate its …

Assessment Of The Probability Of Loggerhead Sea Turtle (Caretta Caretta) Recovery In The Northwest Atlantic Ocean Within 50 Years Of Federal And State Protection In The Us, Michael D. Arendt

Theses and Dissertations

Systematic implementation of sea turtle conservation measures have occurred in the U.S. since the 1970’s. As such, this dissertation assessed the probability that loggerhead sea turtles (Caretta caretta) in the NW Atlantic will meet or exceed recovery criteria in the minimum timeframe (i.e., 50 years) specified by the Recovery Plan. Mathematical modeling (Chapter 1) of a theoretical population resembling an important nesting assemblage in a stochastic environment for 200 years revealed broad (<20k to >106k) fluctuation in annual nest counts without extinction, as well as strong contemporary environmental influence on annual nest counts. Modeling also substantiated the importance of monitoring the …