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Full-Text Articles in Life Sciences
The Roles Of Gsk-3ss And Apc In Cytoplasmic Dynein Regulation, Feng Gao
The Roles Of Gsk-3ss And Apc In Cytoplasmic Dynein Regulation, Feng Gao
Theses and Dissertations
Dynein is a microtubule minus-end directed molecular motor, participating in a broad range of cellular functions, such as organelle transport, cell migration and mitosis. Dynein dysfunction is linked to many diseases including ALS, schizophrenia, Alzheimer’s disease, Parkinson’s disease and cancer. The mechanism of dynein regulation is largely unknown. We have provided evidence that glycogen synthase kinase 3β (GSK-3β) directly regulates dynein in both neurons and non-neuronal cells. GSK-3β interacts with and phosphorylates dynein in vitro. Dynein phosphorylation by GSK-3β reduces its interaction with Ndel1, a regulator contributing to dynein force generation. Dynein motility is stimulated both by pharmacological GSK-3β inhibitors …
Ferric Reductases And Transporters That Contribute To Mitochondrial Iron Homeostasis, Anshika Jain
Ferric Reductases And Transporters That Contribute To Mitochondrial Iron Homeostasis, Anshika Jain
Theses and Dissertations
Iron (Fe) is the fourth most abundant element in the Earth’s crust, yet the availability of Fe to plants is often limited. This is because in most soil types, Fe precipitates as ferric-oxyhydroxy complexes, making it unavailable for uptake by plants. While the mechanisms involved in Fe uptake from the soil are relatively well understood, the mechanisms involved in its further distribution to the aerial portion of the plant and to subcellular compartments are not fully understood. During Fe deprivation, plants up-regulate root Fe acquisition machinery. How plants sense Fe deprivation and tie the Fe status of the plant to …