Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
The Role Of Nitric Oxide Scavenging In Hemoglobin-Based Oxygen Carrier Induced Hypertension: Systemic And Microvascular Effects, Alan Ottarson
The Role Of Nitric Oxide Scavenging In Hemoglobin-Based Oxygen Carrier Induced Hypertension: Systemic And Microvascular Effects, Alan Ottarson
Theses and Dissertations
The purpose of this study was to identify the effects of a hemoglobin-based oxygen carrier, HBOC-201, on the cardiovascular system. Systemic cardiovascular parameters of mean arterial pressure (MAP), pulse pressure, heart rate, and oxygen saturation, as well as vascular resistance, were examined. A murine model of the cardiovascular system and microvasculature was employed. Sprague-Dawley rats (male; 230-530g; N = 13) were anaesthetised and surgically prepared for intravital microscopy of the spinotrapezius muscle. Increasing doses of HBOC-201 (2 mg/kg, 22 mg/kg, 230 mg/kg, and 780 mg/kg) and an iso-oncotic volume control were administered to assess for a dose-response relationship. MAP displayed …