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Full-Text Articles in Life Sciences
The Impact Of Prenatal Vape Exposure On Weanling Liver Gene Expression, Isabella R. Fieger, Cristina Isabel Pauig, Mindy Yin, Anna Lipinski, Barrett Blevins, Tyler Plake, Lucas Georges, Katelyn Chism, Isaiah Burciaga, Selma Podbicanin, Cynthia Corbitt, Rachel Neal
The Impact Of Prenatal Vape Exposure On Weanling Liver Gene Expression, Isabella R. Fieger, Cristina Isabel Pauig, Mindy Yin, Anna Lipinski, Barrett Blevins, Tyler Plake, Lucas Georges, Katelyn Chism, Isaiah Burciaga, Selma Podbicanin, Cynthia Corbitt, Rachel Neal
The Cardinal Edge
The use of E-cigarettes is a fairly recent phenomenon. Vaping is seen as the “healthier” alternative to smoking cigarettes, yet we know little about the developmental toxicity of commercially available vaping products. In the current study, C57Bl/6 mice were exposed to Vuse Alto Golden Tobacco pods (5% nicotine) 4 days before mating and throughout gestation (GD19) for 1 hour/day every day. Offspring birth outcomes were measured with liver tissue collected at weaning. Gross histology and gene expression in the SIRT1-FXR pathway were examined via qPCR analysis with male and female offspring analyzed separately. No differences in gross morphology or cell …