Open Access. Powered by Scholars. Published by Universities.®
School of Biological Sciences: Faculty Publications
Archaeon; heat shock; hyperthermophile; stress response; Sulfolobus solfataricus; toxin–antitoxin locus
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Role Of Vapbc Toxin–Antitoxin Loci In The Thermal Stress Response Of Sulfolobus Solfataricus, Charlotte R. Cooper, Amanda J. Daugherty, Sabrina Tachdjian, Paul H. Blum, Robert M. Kelly
Role Of Vapbc Toxin–Antitoxin Loci In The Thermal Stress Response Of Sulfolobus Solfataricus, Charlotte R. Cooper, Amanda J. Daugherty, Sabrina Tachdjian, Paul H. Blum, Robert M. Kelly
School of Biological Sciences: Faculty Publications
TA (toxin–antitoxin) loci are ubiquitous in prokaryotic microorganisms, including archaea, yet
their physiological function is largely unknown. For example, preliminary reports have suggested
that TA loci are microbial stress-response elements, although it was recently shown that knocking
out all known chromosomally located TA loci in Escherichia coli did not have an impact on
survival under certain types of stress. The hyperthermophilic crenarchaeon Sulfolobus solfataricus
encodes at least 26 vapBC (where vap is virulence-associated protein) family TA loci in its
genome. VapCs are PIN (PilT N-terminus) domain proteins with putative ribonuclease activity,
while VapBs are proteolytically labile proteins, which purportedly function …