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Full-Text Articles in Life Sciences
352 - Quantifying Variation Of The Ostrich Wing (Aves: Paleognathae), Isabel Marzec
352 - Quantifying Variation Of The Ostrich Wing (Aves: Paleognathae), Isabel Marzec
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The common Ostrich (Struthio camelus) is a member of a large clade of flightless birds known as the ratites. The ratites are morphologically classified by their absence of a keeled sternum that, in flighted birds, provides a large surface area for flight muscle attachment. Although morphology in flighted birds is relatively constrained, the lack of selective pressures in ratites has led to increased variability in the wing. The skeleton of S. camelus exhibits numerous adaptations related to cursoriality, such as a double patella, shortened wing skeleton, and a lightweight pelvic girdle. Though their wings may not be capable …
245 - P27kip1 Is Upregulated In Umscv-4 Cells Corresponding To Entering A State Of Quiescence When Treated With Clobetasol., Gianna Minnuto, Luke North, Mack Ogden, Kia Haering
245 - P27kip1 Is Upregulated In Umscv-4 Cells Corresponding To Entering A State Of Quiescence When Treated With Clobetasol., Gianna Minnuto, Luke North, Mack Ogden, Kia Haering
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Quiescence, the temporary exit from the cell cycle, presents therapeutic challenges to cancer management since it allows evasion of chemotherapy and radiotherapy treatment. Essential to the study of quiescence in carcinogenesis is an established model system. Our studies have found that clobetasol treatment of the vulvar cancer cell line, UMSCV-4 causes these cells to enter a state of dormancy. Subsequent removal of the cells from clobetasol show a return to normal cell proliferation, even after dormancy for 3 months. p27Kip1 protein is elevated in quiescent cells and has been used as a marker for entry into quiescence. Using both …
162 - The Importance Of Chaf-1b And P53 In Zebrafish Apoptosis, Noé Stephens, Dhavan Brahmbhatt, Isabel Reitano-Stayer, Hannah Haws
162 - The Importance Of Chaf-1b And P53 In Zebrafish Apoptosis, Noé Stephens, Dhavan Brahmbhatt, Isabel Reitano-Stayer, Hannah Haws
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Chromatin assembly factor-1b (Caf-1b), one of the subunits of Chromatin assembly factor-1, is integral for retina differentiation in both humans and zebrafish. Fisher et. al found that apoptosis was stimulated in cells that lack Caf-1b at the S-phase check point by the tumor suppressor p53 as cells that lacked Caf-1b had a much higher expression of p53 then cells that contained Caf-1b. Fisher et. al proposed the model that Caf-1b is an inhibitor of p53 which stimulates apoptosis in the absence of Caf-1b (2007). However, it is not known what occurs when both Caf-1b and p53 are both removed. If …
256 - Development Of Molecular Markers From The Transcriptome Of An Ant-Mimicking Spider For Population Genetic Analyses, Anna Schell
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The ant-mimicking spider, Myrmarachne formicaria, is a species of jumping spider that is native to Eurasia but has been sighted in North America starting in 2001. This spider is distinctive because of the way it imitates ants by moving its front two legs around like an ant’s antennae. As it is not native to North America, it must have been introduced to the country, but there is not currently enough information to determine whether there was only one introduction event or several different events. We can distinguish between these scenarios and learn more about this spider's dispersal history by analyzing …
122 - Using Crispr/Cas9 Genome Editing To Knockout Mhc Class I In Xenopus Laevis, Keely Glasheen, David Marx, Jacques Robert
122 - Using Crispr/Cas9 Genome Editing To Knockout Mhc Class I In Xenopus Laevis, Keely Glasheen, David Marx, Jacques Robert
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The immune system of the frog Xenopus laevis is similar to humans. MHC Class I is a vital molecule for the immune system of Xenopus laevis. It presents peptides to CD8 T-cells and the presentation of self peptide fragments is crucial for immune self recognition. When MHC Class I presents non-self peptide fragments, it triggers an immune response, causing CD8 T-cells to kill the infected cells. All cells express some level of MHC Class I because all cells can be infected. The role this molecule plays in immune function and self recognition is of particular interest in Xenopus laevis since …
193 - Biological Trends In Schistosomiasis Reinfections And Co-Infections, David Marx, Tyler Dzuba, Wai Cheung Tung
193 - Biological Trends In Schistosomiasis Reinfections And Co-Infections, David Marx, Tyler Dzuba, Wai Cheung Tung
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Schistosomiasis is a parasitic infection that affected nearly 252 million people worldwide in 2021, Africa, Asia, and South America are the most affected regions. Schistosomiasis can cause many symptoms, many of which are seen through urinalysis. Due to the nature of Schistosoma mansoni and S. haematobium reinfection is quite common. Coinfection also between these two species occurs frequently due to the overlap in areas they affect. Both reinfection and coinfection are possible causes for differences in severity of infection. The severity of infection can be determined both in terms of the symptoms of the afflicted individual as well as looking …
204 - How Does Change In Land Use Impact The Water Chemistry Parameters In The Streams Of Oswego County, Ny, Madison Steates, Thomas Back
204 - How Does Change In Land Use Impact The Water Chemistry Parameters In The Streams Of Oswego County, Ny, Madison Steates, Thomas Back
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Land use within a watershed is closely tied to stream water chemistry. Anthropogenic chemical inputs eventually make their way into streams, affecting fluvial ecosystems. Sources of these anthropogenic inputs change over time, especially when rural landscapes become increasingly urbanized. We studied the relationship between land use and stream water chemistry for Oswego County, New York, because riparian zones in this county have shifted to residential from agricultural and forested land uses. We extracted data from the New York State Department of Conservation (DEC) Department of Water (DOW) Monitoring Portal. Preliminary results show that Total Nitrogen (Kjeldahl) in mg/L fluctuates yearly …
237 - Seasonal And Historical Trends Of Cyanobacteria Dominance In Conesus Lake, Emma Belica, Isabella Imbo
237 - Seasonal And Historical Trends Of Cyanobacteria Dominance In Conesus Lake, Emma Belica, Isabella Imbo
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The purpose of this research was three-fold. First, an analysis of long-term data was conducted to determine how the abundance of the cyanobacteria of the genus Dolichospermum changed historically since 1985 in Conesus Lake. Secondly, to look at the seasonality of the Dolichospermum blooms in the Summer of 2022. Third, to determine Dolichospermum's Nitrogen-fixing activity based on analysis of the frequency of Nitrogen-fixing cells in the population (heterocysts). Long-term data shows Dolichospermum has increased in representation in recent years and in 2022 reached a peak biomass that represented 75% of all the cyanobacteria biomass and 56% of all the phytoplankton …
146 - Localization Of Sonic Hedgehog (Shh) Protein In Zebrafish, Muwafuq Ibrahim, Jacqueline Maloney, Christopher Jung, Zee Ralph, Isabell Mathew
146 - Localization Of Sonic Hedgehog (Shh) Protein In Zebrafish, Muwafuq Ibrahim, Jacqueline Maloney, Christopher Jung, Zee Ralph, Isabell Mathew
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Zebrafish possess a unique ability to regenerate their retina when damaged; our objective is to gain a better understanding regarding retinal regeneration in zebrafish in hopes of eventually utilizing this information to promote retinal regeneration in humans. It has been shown that a protein, Sonic Hedgehog signaling protein (shh), plays a role in the differentiation of progenitor cells during eye development in zebrafish. Researchers have concluded that shh moves across the retina in a wave-like fashion during vertebrate development and regeneration. Studies have been conducted to see how the shh protein moves, but none have investigated the exact location that …
242 - Validating Zebrafish Chaf1b Antibody, Brianna Donlon, Stephen Welsch, Emma Hatch
242 - Validating Zebrafish Chaf1b Antibody, Brianna Donlon, Stephen Welsch, Emma Hatch
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Zebrafish embryos that are homozygous for gef mutant alleles experience a small-eye phenotype, due to a coding change in the chaf1b gene that results in a prematurely truncated protein. It's thought that the Chaf1b protein is required for all dividing cells to survive the DNA replication phase of the cell cycle. Contradicting these findings, the proliferating cells of the gef mutant embryos do not start to prematurely die until they are two days old. One question of delayed death in zebrafish is whether the normal protein can be provided by the heterozygous mother. If so, this would account for how …