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Regulation Of Learning And Memory By The Drosophila Melanogaster Swi/Snf Complex, Max H. Stone
Regulation Of Learning And Memory By The Drosophila Melanogaster Swi/Snf Complex, Max H. Stone
Electronic Thesis and Dissertation Repository
The SWI/SNF complex is a highly-conserved ATP-dependent chromatin remodelling complex that is important in the etiology of intellectual disability (ID). I systematically investigated the overall and adult-specific roles of each of the 15 Drosophila melanogaster SWI/SNF complex components in memory. Flies with RNAi-mediated knockdown of individual SWI/SNF genes in the mushroom body (MB) were tested for short- and long-term memory impairment using courtship conditioning. Knockdown of several SWI/SNF genes through development, including brahma, Bap60, Snr1, and e(y)3, caused loss of memory. Adult-specific knockdown of SWI/SNF genes caused some loss of memory phenotypes, indicating an acute role in adult MB activity. …
The Effect Of Age On Social Behaviour In Drosophila Melanogaster And The Progeny Of Aged Parents, Dova Brenman
The Effect Of Age On Social Behaviour In Drosophila Melanogaster And The Progeny Of Aged Parents, Dova Brenman
Electronic Thesis and Dissertation Repository
Recent studies have linked neuropsychiatric disorders to older parents. These disorders often include changes in social behaviours like the social spacing between neighbouring individuals, which can be modeled in organisms such as Drosophila melanogaster. I investigated the effects of aging on the social space between neighbouring D. melanogaster and how aging impacts the next generation. To achieve this, I used the social space assay and found that individuals become less social with age and that this effect is passed on to the first generation only. Additionally, accelerating the physiological process of aging via increased rearing temperatures or exposure to …