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The Epigenetic Regulation Of Cytokine Inducible Mammalian Transcription By The 26s Proteasome, Olivia I. Koues
The Epigenetic Regulation Of Cytokine Inducible Mammalian Transcription By The 26s Proteasome, Olivia I. Koues
Biology Dissertations
It is evident that components of the 26S proteasome function beyond protein degradation in the regulation of transcription. Studies in yeast implicate the 26S proteasome, specifically the 19S cap, in the epigenetic regulation of transcription. Saccharomyces cerevisiae 19S ATPases remodel chromatin by facilitating histone acetylation and methylation. However, it is unclear if the 19S ATPases play similar roles in mammalian cells. We previously found that the 19S ATPase Sug1 positively regulates transcription of the critical inflammatory gene MHC-II and that the MHC-II promoter fails to efficiently bind transcription factors upon Sug1 knockdown. MHC-II transcription is regulated by the critical coactivator …