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Thermodynamic And Structural Characterization Of The Interaction Between Wd40 Repeat Containing Protein 5 (Wdr5) And Human Set1 Family Methyltransferases, Venkat Dharmarajan
Thermodynamic And Structural Characterization Of The Interaction Between Wd40 Repeat Containing Protein 5 (Wdr5) And Human Set1 Family Methyltransferases, Venkat Dharmarajan
Biology - Dissertations
Translocations and amplifications of the mixed lineage leukemia-1 (MLL1) gene are associated with aggressive myeloid and lymphocytic leukemias in humans. MLL1 is a member of the SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, which are required for transcription of genes involved in hematopoiesis and development. MLL1 associates with a sub-complex containing WDR5, RbBP5, Ash2L, and DPY-30 (WRAD), which together form the MLL1 core complex that is required for sequential mono- and dimethylation of H3K4. We previously demonstrated that WDR5 binds the conserved WDR5 interaction (Win) motif of MLL1 in vitro, an interaction that is required for the H3K4 …