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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Tracking The Progression Of Defects At The Neuromuscular Junction In Huntington's Disease, Katherine A. Trittschuh
Tracking The Progression Of Defects At The Neuromuscular Junction In Huntington's Disease, Katherine A. Trittschuh
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Huntington’s disease (HD) is a genetic disorder associated with progressive cognitive and motor decline. Recent studies in HD models suggest primary peripheral pathologies arise independent of changes in the central nervous system. Our lab found defects in skeletal muscle occurring early in the progression of disease in transgenic R6/2 HD mice, resulting in membrane hyperexcitability. Additionally, there is evidence of decreased quantal content in late-stage R6/2 mice. Here, we investigate pre-synaptic and post-synaptic function at single neuromuscular junctions (NMJ) to make direct comparisons of disease progression in the muscle membrane and motor nerve terminal. We hypothesize that muscle membrane defects …
Tracking The Progression Of Defects At The Neuromuscular Junction In Huntington's Disease, Katherine A. Trittschuh
Tracking The Progression Of Defects At The Neuromuscular Junction In Huntington's Disease, Katherine A. Trittschuh
Browse all Theses and Dissertations
Huntington’s disease (HD) is a genetic disorder associated with progressive cognitive and motor decline. Recent studies in HD models suggest primary peripheral pathologies arise independent of changes in the central nervous system. Our lab found defects in skeletal muscle occurring early in the progression of disease in transgenic R6/2 HD mice, resulting in membrane hyperexcitability. Additionally, there is evidence of decreased quantal content in late-stage R6/2 mice. Here, we investigate pre-synaptic and post-synaptic function at single neuromuscular junctions (NMJ) to make direct comparisons of disease progression in the muscle membrane and motor nerve terminal. We hypothesize that muscle membrane defects …
The Impact Of Study Strategies On Academic Performance For Medical Students At Wright State University, Markia Black
The Impact Of Study Strategies On Academic Performance For Medical Students At Wright State University, Markia Black
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Studying plays an important role in the academic success of medical students. It is likely that ineffective study skills result in poor performances on required standardized exams. There is a concern for the lack of empirical data related to what study strategies are the most productive for medical students to practice. My goal is to 1) identify what study strategies students use in their pre-clinical years of medical school, 2) determine if these strategies impact students’ performance on Comprehensive Basic Science Exams and Step 1 exam, and 3) identify study methods that best support student achievement in the pre-clinical phase …
Microplastics In Wetlands Of West Central Ohio : Concentration And Distribution, Mitchell Link
Microplastics In Wetlands Of West Central Ohio : Concentration And Distribution, Mitchell Link
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Wetlands provide many valuable ecosystem services; however, an emerging global contaminant—microplastic (< 5 mm)—may be degrading this important resource. Few studies have extensively surveyed microplastic distribution in wetlands over a broad spatial area. Therefore, the goal of this study is to identify where microplastics are accumulating in wetlands, and whether there is any correlation between microplastic concentration and wetland quality. Soil samples were collected from 30 wetlands in west–central Ohio. Samples were physically separated, density separated, and digested. Average microplastic concentrations were 637 ± 494 items per kg soil per wetland. Higher quality wetlands are accumulating larger concentrations of microplastics. This relationship seems to be driven by greater accumulation of microplastics in forested wetlands than in wetlands surrounded by agriculture. There is no clear distribution pattern of microplastics within wetlands. These results provide insight into the role that wetlands have in association with microplastic accumulation.
To What Extent Do Non-Native Shrubs Support Higher Trophic Levels?, Ari Zakroff
To What Extent Do Non-Native Shrubs Support Higher Trophic Levels?, Ari Zakroff
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Invasive species threaten ecosystems and economies. Globally, biological invasions are estimated to have cost over $2.1 trillion since 1970. In Eastern North American woodlands, invasive plants are rapidly displacing natives. This is concerning, because invasive plants may not support the diverse and abundant arthropod communities essential to ecosystem function. Despite the conceptual understanding of invasive shrubs’ potential to transform forest communities, scant research has focused on the effect of invasive plants on higher trophic levels here in Ohio. To address this gap, I examined the diversity and abundance of arthropod communities, caterpillar performance, and caterpillar predation on two invasive shrubs, …