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Central Precocious Puberty Alters The Mammary Gland Epithelial Landscape In Female Rats, Alina M. Hamilton
Central Precocious Puberty Alters The Mammary Gland Epithelial Landscape In Female Rats, Alina M. Hamilton
Theses and Dissertations
Precocious puberty (PP) is a serious endocrine disorder associated with an increased risk for development of breast cancer (BC) later in life. However, the lack of a strong in vivo model has made it difficult to study this relationship. Our group has established manganese (Mn) as a non-toxic activator of the pubertal process. Recently we demonstrated that Mn-induced precocious puberty (MnPP) accelerates E2-regulated mammary gland (MG) development in prepubertal female rats, resulting in persistent proliferation and adult hyperplasia. Using this model, I demonstrate that precocious puberty alters steroidal regulation of proliferation in both the prepubertal and adult virgin MG, altering …