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Full-Text Articles in Life Sciences
A Model Of The Use Of Evolutionary Trees (Muet) To Inform K-14 Biology Education, Yi Kong, Ankita Thawani, Trevor R. Anderson, Nancy Pelaez
A Model Of The Use Of Evolutionary Trees (Muet) To Inform K-14 Biology Education, Yi Kong, Ankita Thawani, Trevor R. Anderson, Nancy Pelaez
PIBERG Publications
Evolutionary trees are powerful tools used in modern biological research, and also commonly used in textbooks and classroom instruction. Studies have shown that K-14 students have difficulties interpreting evolutionary trees. To improve student learning about this topic, it is essential to teach them how to understand and use trees like professional biologists. Unfortunately, few currently used teaching frameworks for evolution instruction are designed for this purpose. In this study we developed the Model of the Use of Evolutionary Trees (MUET), a conceptual model that characterizes how evolutionary trees were used by professional biologists as represented in their research publications. The …
Loss Of Myod Promotes Fate Transdifferentiation Of Myoblasts Into Brown Adipocytes, Chao Wang, Weiyi Liu, Yaohui Nie, Mulan Qaher, Hannah Elizabeth Horton, Feng Yue, Atsushi Asakura, Shihuan Kuang
Loss Of Myod Promotes Fate Transdifferentiation Of Myoblasts Into Brown Adipocytes, Chao Wang, Weiyi Liu, Yaohui Nie, Mulan Qaher, Hannah Elizabeth Horton, Feng Yue, Atsushi Asakura, Shihuan Kuang
Department of Animal Sciences Faculty Publications
Brown adipose tissue (BAT) represents a promising agent to ameliorate obesity and other metabolic disorders. How- ever, the abundance of BAT decreases with age and BAT paucity is a common feature of obese subjects. As brown adipocytes and myoblasts share a common Myf5 lineage origin, elucidating the molecular mechanisms underlying the fate choices of brown adipocytes versus myoblasts may lead to novel approaches to expand BAT mass. Here we identify MyoD as a key negative regulator of brown adipocyte development. CRISPR/CAS9-mediated deletion of MyoD in C2C12 myoblasts facilitates their adipogenic transdifferentiation. MyoD knockout downregulates miR- 133 and upregulates the miR-133 …
Prediction Of Local Quality Of Protein Structure Models Considering Spatial Neighbors In Graphical Models., Woong Hee Shin, Xuejiao Kang, Jian Zhang, Daisuke Kihara
Prediction Of Local Quality Of Protein Structure Models Considering Spatial Neighbors In Graphical Models., Woong Hee Shin, Xuejiao Kang, Jian Zhang, Daisuke Kihara
Department of Biological Sciences Faculty Publications
Protein tertiary structure prediction methods have matured in recent years. However, some proteins defy accurate prediction due to factors such as inadequate template structures. While existing model quality assessment methods predict global model quality relatively well, there is substantial room for improvement in local quality assessment, i.e. assessment of the error at each residue position in a model. Local quality is a very important information for practical applications of structure models such as interpreting/designing site-directed mutagenesis of proteins. We have developed a novel local quality assessment method for protein tertiary structure models. The method, named Graph-based Model Quality assessment method …