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The Effect Of Apremilast On Circadian Rhythm In The Ventral Tegmental Area, Courtney Ledford, Angela Ozburn
The Effect Of Apremilast On Circadian Rhythm In The Ventral Tegmental Area, Courtney Ledford, Angela Ozburn
McNair Symposium
Chronic binge drinking negatively impacts society and is a leading cause of preventable deaths. The purpose of the experiment is to determine if regulation of circadian rhythms in the ventral tegmental area (VTA) will contribute to less ethanol consumption. The VTA plays a major role in addiction. A simple genetic animal model examines iHDID-1 mice and their binge-like drinking intake. The mice undergo Drinking in the Dark (DID) for 6 weeks prior to administration of apremilast or saline treatment at weeks 7 and 8. The mice are exposed to DID and sacrificed at two separate time points (ZT 3 and …