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Full-Text Articles in Life Sciences
Eutherian Biogeography During The Puercan North American Land Mammal Age (Paleocene, Earliest Danian): Problems And Potential Solutions, Jason Sterling Silviria
Eutherian Biogeography During The Puercan North American Land Mammal Age (Paleocene, Earliest Danian): Problems And Potential Solutions, Jason Sterling Silviria
Earth and Planetary Sciences ETDs
The Puercan North American Land Mammal Age (NALMA) is the earliest major North American terrestrial biochron of the Cenozoic era, spanning roughly the first one million years of the Paleogene period (Paleocene epoch, Danian stage; ~66.04-65.12 Ma). It is typified by the explosive ecomorphological diversification of the mammalian clade Eutheria (particularly our subclade, Placentalia), following the annihilation of non-avian dinosaurs and “archaic” mammal groups during the Cretaceous/Paleogene (K-Pg) mass extinction event. The spatiotemporal mode and tempo of Puercan eutherian diversification has long been the subject of debate, with disagreements over biogeographic zonation. The traditional model – based largely on well-sampled, …
Contribution Of Retrotransposons To Breast Cancer Malignancy, Isaac D. Raplee
Contribution Of Retrotransposons To Breast Cancer Malignancy, Isaac D. Raplee
USF Tampa Graduate Theses and Dissertations
The components contributing to cancer progression, especially the transition from early to invasive are unknown. Consequently, the biological reasons are unclear as to why some patients diagnosed with atypia and ductal carcinoma in situ (DCIS) never progress into invasive breast cancer. The “one gene at a time” approach does not sufficiently predict progression. To elucidate the early stage progression to invasive ductal cancer, expression signature of transcripts and transposable elements in micropunched samples of formalin-fixed, paraffin embedded (FFPE) tissue was conducted. A bioinformatics pipeline to analyze poor quality, short reads (>36 nts) from RNA-Seq data was created to compare …
Genomics And Transcriptomics Approaches To Understanding Drug Resistance Mechanisms In The Malaria Parasite Plasmodium Falciparum, Justin Allan Gibbons
Genomics And Transcriptomics Approaches To Understanding Drug Resistance Mechanisms In The Malaria Parasite Plasmodium Falciparum, Justin Allan Gibbons
USF Tampa Graduate Theses and Dissertations
The malaria parasite Plasmodium falciparum is responsible for about 500,000 deaths a year and is evolving resistance to the front-line treatment of artemisinin-based combination therapy. Resistance is currently confined to South East Asia, however millions of lives will be at risk if resistance spreads to Africa. Understanding the mechanism of resistance to artemisinins would aid containment strategies to prevent the spread of artemisinin resistance. There is also an urgent need to accelerate drug discovery since drug resistance has already been documented to all existing antimalarials. Here, I report on our efforts to understand the function of the gene k13, the …