Life Sciences Commons^™

Expression Analysis Of Hif-1a And Hif-2a Genes In Tibetan Chicken Under Normoxia And Hypoxia.Pdf, Yunzhou Yang, Ying Bai, Xinxing Dong, Jibin Zhang, Meiying Fang

Jibin Zhang

A Review Of International Best Practice In E-Governmentsome Lessons For New Adopters, Deogratias Harorimana Sr

Dr Deogratias Harorimana

Efficient bureaucratic processes as essential to attract and retain investment, as well as promote SME growth. The e_Gov is one of many ways emerging economies have used to streamline public service delivery and create a freindly and conducive atmosphere for business -both MNC and SMEs. This presentation provide an overview of some of the World's most recent case examples on the successful design-plan-implementation of eGov to build a strong basis to attract investment and deliver seamless essential services to Citizens.

A Critical Review Of The Effectiveness Of Fiscal And Monetary Policies In The Pacific Island Countries (Pics) Between 1990-2010, Deogratias Harorimana Mr

Dr Deogratias Harorimana

The purpose of this paper is to critically assess the effectiveness of Fiscal and Monetary Policies in the South Pacific Island Countries. The paper tracks down the economic growth for the last 20 years between 1990-2010, and drawing from key fiscal and monetary policies in place during the time under consideration, as well as specific interventions in the region, we find that: 1) While the South Pacific Island Countries (SPICs) particularly the six major economies (Solomon Islands, Fiji, Vanuatu, PNG, Samoa, Tonga) pursued fiscal and monetary policies for promoting growth and diversification of their economies, their fiscal policies relied heavily …

Issues In Human Capital Development : Lessons For Public Administration And Governance, Deogratias Harorimana Mr

Dr Deogratias Harorimana

With few minerals or other natural resources, Rwanda believes that she can still achieve her ambitions by investing in human capital - her unique resource. If this ambition can be achieved, then is this the next role model for international development? We used a case study design and analysis methods to examine development models used elsewhere in recent decades, using both qualitative and quantitative data on Rwanda to establish the comparative advantages in relation to Singapore’s economic development model. The implications for international development are that (1) an effective human capital development strategy should be inclusive enough to respond to …

The Use Of Imputed Values In The Meta-Analysis Of Genome-Wide Association Studies., Shuo Jiao, Li Hsu, Carolyn Hutter, Ulrike Peters

Shuo Jiao

In genome-wide association studies (GWAS), it is a common practice to impute the genotypes of untyped single nucleotide polymorphism (SNP) by exploiting the linkage disequilibrium structure among SNPs. The use of imputed genotypes improves genome coverage and makes it possible to perform meta-analysis combining results from studies genotyped on different platforms. A popular way of using imputed data is the "expectation-substitution" method, which treats the imputed dosage as if it were the true genotype. In current practice, the estimates given by the expectation-substitution method are usually combined using inverse variance weighting (IVM) scheme in meta-analysis. However, the IVM is not …

Muc4 Modulation Of Ligand-Independent Erbb2 Signaling, Goldi Attias Kozloski

Goldi A Kozloski

The membrane mucin Muc4 is a heterodimer, bi-functional glycoprotein complex that is normally expressed in epithelial tissue. Functional studies on the extracellular mucin subunit of Muc4 have shown that it acts to promote anti-adhesion properties by sterically interfering with cell-cell and cell-matrix interactions and that the extent of this effect is directly associated with the number of tandem repeats on this subunit. Functional studies on the transmembrane subunit of Muc4 have shown that this subunit participates in intracellular signaling through interaction with the receptor tyrosine kinase ErbB2. This role of Muc4 was shown to be mediated by stabilizing the heregulin …

Micrornas Are Independent Predictors Of Outcome In Diffuse Large B-Cell Lymphoma Patients Treated With R-Chop, Goldi Kozloski

Goldi A Kozloski

Acute Toxicity Of Mercury And Chromium To Clarias Batrachus (Linn), Azhaguraj Ramakrishnan

Azhaguraj Ramakrishnan

Pollution of the aquatic ecosystems by heavy metals is a worldwide problem. In the present study, Clarias batrachus was exposed to Mercury and Chromium for 24, 48, 72 and 96 hrs. The median lethal concentration (LC50) of mercury to C. batrachus for 24, 48, 72 and 96 h of exposure were 1.4 ppm, 1.2 ppm, 1.0 ppm and 0.8 ppm respectively. The median lethal concentration (LC50) of chromium to C. batrachus for 24, 48, 72 and 96 h of exposure were 120 ppm, 115 ppm, 110 ppm and 102 ppm respectively. The acute toxicity levels were derived from LC50 concentrations …

Evolution And Quantitative Comparison Of Genome-Wide Protein Domain Distributions, Arli A. Parikesit, Peter F. Stadler, Sonja J. Prohaska

Arli A Parikesit

The metabolic and regulatory capabilities of an organism are implicit in its protein content. This is often hard to estimate, however, due to ascertainment biases inherent in the available genome annotations. Its complement of recognizable functional protein domains and their combinations convey essentially the same information and at the same time are much more readily accessible, although protein domain models trained for one phylogenetic group frequently fail on distantly related sequences. Pooling related domain models based on their GO-annotation in combination with de novo gene prediction methods provides estimates that seem to be less affected by phylogenetic biases. We show …

Clustering With Exclusion Zones: Genomic Applications, Mark Segal, Yuanyuan Xiao, Fred Huffer

Mark R Segal

Methods for formally evaluating the clustering of events in space or time, notably the scan statistic, have been richly developed and widely applied. In order to utilize the scan statistic and related approaches, it is necessary to know the extent of the spatial or temporal domains wherein the events arise. Implicit in their usage is that these domains have no “holes”—hereafter “exclusion zones”—regions in which events a priori cannot occur. However, in many contexts, this requirement is not met. When the exclusion zones are known, it is straightforward to correct the scan statistic for their occurrence by simply adjusting the …

Evolution Of Domain Co-Occurrences: Some Striking Results, Arli A. Parikesit, Peter F. Stadler, Sonja J. Prohaska

Arli A Parikesit

No abstract provided.