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A Discrete-Event Simulation Approach For Modeling Human Body Glucose Metabolism, Buket Aydas
A Discrete-Event Simulation Approach For Modeling Human Body Glucose Metabolism, Buket Aydas
Theses and Dissertations
This dissertation describes CarbMetSim (Carbohydrate Metabolism Simulator), a discrete-event simulator that tracks the blood glucose level of a person in response to a timed sequence of diet and exercise activities. CarbMetSim implements broader aspects of carbohydrate metabolism in human beings with the objective of capturing the average impact of various diet/exercise activities on the blood glucose level. Key organs (stomach, intestine, portal vein, liver, kidney, muscles, adipose tissue, brain and heart) are implemented to the extent necessary to capture their impact on the production and consumption of glucose. Key metabolic pathways (glucose oxidation, glycolysis and gluconeogenesis) are accounted for by …
Facilitating And Enhancing Biomedical Knowledge Translation: An In Silico Approach To Patient-Centered Pharmacogenomic Outcomes Research, Kourosh Ravvaz
Facilitating And Enhancing Biomedical Knowledge Translation: An In Silico Approach To Patient-Centered Pharmacogenomic Outcomes Research, Kourosh Ravvaz
Theses and Dissertations
Current research paradigms such as traditional randomized control trials mostly rely on relatively narrow efficacy data which results in high internal validity and low external validity. Given this fact and the need to address many complex real-world healthcare questions in short periods of time, alternative research designs and approaches should be considered in translational research. In silico modeling studies, along with longitudinal observational studies, are considered as appropriate feasible means to address the slow pace of translational research. Taking into consideration this fact, there is a need for an approach that tests newly discovered genetic tests, via an in silico …