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Gene Regulatory Context Of Honey Bee Worker Sterility, Rahul Choorakkat Unnikrishnan
Gene Regulatory Context Of Honey Bee Worker Sterility, Rahul Choorakkat Unnikrishnan
Electronic Thesis and Dissertation Repository
Honey bee workers deactivate their ovaries and are functionally sterile when a queen is present in the colony. I adopt a bioinformatics approach to up-date a model transcriptional regulatory network (TRN) to study gene-regulatory processes that regulate fecundity in workers. On splitting the network, I obtained nine clusters and each cluster conformed to properties associated with real-world networks. Two of the nine clusters are enriched for 'sterility genes' and contained single well-connected hub genes (GB44769, ftz-f1). The genes in the two clusters were functionally enriched for nucleic acid binding (GO:0003676) and nucleotide binding (GO:0000166). I identified homologous genes for …