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Full-Text Articles in Life Sciences
Functional Analysis Of Sin3 Isoforms In Drosophila, Nirmalya Saha
Functional Analysis Of Sin3 Isoforms In Drosophila, Nirmalya Saha
Wayne State University Dissertations
he multisubunit SIN3 complex is a global transcriptional regulator. In Drosophila, a single Sin3A gene encodes different isoforms of SIN3, of which SIN3 187 and SIN3 220 are the major isoforms. Previous studies have demonstrated functional non-redundancy of SIN3 isoforms. The role of SIN3 isoforms in regulating distinct biological processes, however, is not well characterized. In addition, how the components of the SIN3 complex modulate the gene regulatory activity of the complex is not well understood. In this study, I identified the biological processes regulated by the SIN3 isoforms. Additionally, I explored how Caf1-55 impacts the gene regulatory activity of …
Network-Based Approaches To Identify The Impacted Genes And Active Interactions, Sahar Ansari
Network-Based Approaches To Identify The Impacted Genes And Active Interactions, Sahar Ansari
Wayne State University Dissertations
A very important step in system biology is the identification of the networks that are most impacted in the given phenotype.
Such networks explain where the target genes are affected by some other genes, and therefore describe the mechanisms involved in a biological process.
The identified networks are used to: 1) predict the disease or the responses of the system to a specific impact, 2) find the subset of genes that interact with each other and play an important role in the condition of interest, and 3) understand the mechanisms involved in that condition.
In this thesis, we propose an …
Horizontal And Vertical Integration Of Bio-Molecular Data, Tin Chi Nguyen
Horizontal And Vertical Integration Of Bio-Molecular Data, Tin Chi Nguyen
Wayne State University Dissertations
Modern biomedical research lies at the crossroads of data gathering, interpretation, and hypothesis testing. Due to noise, study bias, or too small changes in biological signals between disease and healthy, individual studies often fail to identify the true phenomenon. Data integration is the key to obtaining the power needed to pinpoint the biological mechanisms of disease states. Given this, we tried to make important contributions in both horizontal and vertical integration of high-throughput data; the former is meta-analysis of independent studies, while the latter is the integration of multi-omics data.
For horizontal meta-analysis, we developed two frameworks: DANUBE and the …