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Genome-Wide Analysis Of Clustered Dorsal Binding Sites Identifies Putative Target Genes In The Drosophila Embryo, Michele Markstein, Peter Markstein, Vicky Markstein, Michael Levine
Genome-Wide Analysis Of Clustered Dorsal Binding Sites Identifies Putative Target Genes In The Drosophila Embryo, Michele Markstein, Peter Markstein, Vicky Markstein, Michael Levine
Michele Markstein
Metazoan genomes contain vast tracts of cis-regulatory DNA that have been identified typically through tedious functional assays. As a result, it has not been possible to uncover a cis-regulatory code that links primary DNA sequences to gene expression patterns. In an initial effort to determine whether coordinately regulated genes share a common “grammar,” we have examined the distribution of Dorsal recognition sequences in the Drosophila genome. Dorsal is one of the best-characterized sequence-specific transcription factors in Drosophila. The homeobox gene zerknullt (zen) is repressed directly by Dorsal, and this repression is mediated by a 600-bp silencer, the ventral repression element …