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Effect Of Hinge Region Phosphorylation On The Localization Of Thp1 In Tetrahymena Thermophila, Emily Bulley, Emily Wiley
Effect Of Hinge Region Phosphorylation On The Localization Of Thp1 In Tetrahymena Thermophila, Emily Bulley, Emily Wiley
Scripps Senior Theses
Within the cell nucleus, there are regions of highly condensed, transcriptionally silent chromatin called heterochromatin. Heterochromatin plays an important role in both chromosomal stability and gene regulation within the cell. Heterochromatin assembly is mediated by Heterochromatin Protein 1 (HP1) binding to epigenetically marked histone tails, most notably methylated H3K9. HP1 is post-translationally phosphorylated at serine and threonine residues, and this phosphorylation has been shown to increase HP1’s binding affinity for methylated H3K9 and heterochromatin formation. To study the effect of phosphorylation on heterochromatin assembly and HP1 localization within the nucleus, the unicellular protozoan Tetrahymena thermophila was used. Tetrahymena is an …