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Regulation Of Sparc Gene Expression By The Activator Protein 1 Transcription Factor, Joseph William Briggs
Regulation Of Sparc Gene Expression By The Activator Protein 1 Transcription Factor, Joseph William Briggs
Theses and Dissertations in Biomedical Sciences
Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotypic changes related to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to cellular gene expression patterns. One gene that becomes highly upregulated is SPARC (secreted protein acidic and rich in cysteine). Increased SPARC expression is associated with malignant progression in a variety of different cancers, although little is known regarding the mechanisms of SPARC gene regulation. Therefore, the objectives of this study were: (1) to determine the mechanisms by which c-Jun …