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Full-Text Articles in Life Sciences
Role Of The Hyaluronan Receptor, Stabilin-2/Hare, In Health And Disease, Edward N. Harris, Erika Baker
Role Of The Hyaluronan Receptor, Stabilin-2/Hare, In Health And Disease, Edward N. Harris, Erika Baker
Department of Biochemistry: Faculty Publications
Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans. HA has many biological functions including joint lubrication, ocular turgor pressure, skin elasticity and hydration, cell motility, and intercellular signaling, among many others. The regulatory system for HA content in the tissues, lymphatics, and circulatory systems is due, in part, to Stabilin-2/HARE. The activity of this receptor was discovered about 40 years ago (early 1980s), cloned in the mid-1990s, and has been characterized since then. Here, we discuss the overall domain organization of this receptor and how it correlates to …
Characterization Of The Tsc/Dyrk1a Interaction, Supriya Joshi
Characterization Of The Tsc/Dyrk1a Interaction, Supriya Joshi
Theses and Dissertations
The Tuberous sclerosis complex (TSC) includes TSC1, TSC2 and the TBC1D7 subunits that together function as a principal inhibitor of the mTOR protein kinase complex 1 (mTORC1). mTORC1 is a master regulator of cell growth and proliferation that responds to signaling cues such as growth factors and nutrient availability. Proteomic studies in our lab revealed an interaction between the TSC subunits and DYRK1A, a ubiquitous protein kinase encoded by a gene located in the Down syndrome (DS) region on human chr21. In this study, we sought to validate the interaction of the TSC components with DYRK1A and to determine the …